1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carbothioamide CAS 321534-55-8

Purity 97%+In StockPharmaceutical Standards
CAS No.321534-55-8
Molecular FormulaC10H6ClF3N4S
Molecular Weight306.69 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carbothioamide CAS 321534-55-8 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 306.69 g/mol gives 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carbothioamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carbothioamide (CAS 321534-55-8), molecular formula C10H6ClF3N4S and molecular weight 306.69 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carbothioamide (C10H6ClF3N4S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carbothioamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC10H6ClF3N4S
Molecular Weight306.69 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2025
Halogen ContentF/Cl-containing
Nitrogen Atoms4
Sulfur Atoms1

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