3-Chloro-2-(4-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl)-5-(trifluoromethyl)pyridine CAS 321848-27-5
| CAS No. | 321848-27-5 |
| Molecular Formula | C20H17Cl2F3N4 |
| Molecular Weight | 441.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Chloro-2-(4-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl)-5-(trifluoromethyl)pyridine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-Chloro-2-(4-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl)-5-(trifluoromethyl)pyridine (CAS 321848-27-5), molecular formula C20H17Cl2F3N4 and molecular weight 441.28 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-2-(4-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)piperidin-1-yl)-5-(trifluoromethyl)pyridine (C20H17Cl2F3N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H17Cl2F3N4 |
| Molecular Weight | 441.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 3-Chloro-N-(1-(3-chlorobenzyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinolin-3-yl)benzamide (CAS 477864-91-8)
- (E)-[(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene][(2-chlorophenyl)methoxy]amine (CAS 1092346-31-0)
- (E)-[(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene][(4-chlorophenyl)methoxy]amine (CAS 1092346-35-4)
- 5-Chloro-1-(3-chlorobenzyl)-2-oxo-N-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide (CAS 338977-64-3)
- 5-Chloro-1-[(3-chlorophenyl)methyl]-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (CAS 338977-63-2)
- 5-Chloro-1-[(4-chlorophenyl)methyl]-6-oxo-N-[3-(trifluoromethyl)phenyl]-1,6-dihydropyridine-3-carboxamide (CAS 339024-66-7)
- 5-Chloro-N-(4-chlorophenyl)-6-oxo-1-(3-(trifluoromethyl)benzyl)-1,6-dihydropyridine-3-carboxamide (CAS 339024-12-3)
- 2,3-Bis(4-chloro-3-nitrophenyl)quinoxaline (CAS 130711-05-6)
Recommended Standards
- 3-{4-[(2,4-dichlorophenyl)methoxy]phenyl}-1-(4-fluorobenzoyl)-1H-pyrazole (CAS 477711-57-2)
- Di-tert-butyl (8-bromo-6-fluoroisoquinolin-3-yl)iminodicarbonate (CAS 2842053-26-1)
- Perfluorophenyl 2-morpholino-5-(trifluoromethyl)benzoate (CAS 898289-52-6)
- Methyl 2-[2-(4-bromobenzenesulfonamido)acetamido]-2-phenylacetate (CAS 1100757-01-4)
- (5-Bromo-2-hydroxyphenyl)boronic acid (CAS 89598-97-0)
- (R)-N-(4-Acetylthiazol-2-yl)-2-aminopropanamide (CAS 1344915-09-8)
- 1-(3-(2,3,5,6-Tetramethylphenyl)-9H-benzo[4,5][1,2,3]triazolo[2,1-b][1,2,3,5]oxatriazol-9-yl)ethan-1-one (CAS 391218-35-2)
- 6-(Piperidin-4-yl)pyridin-3-amine hydrochloride (CAS 845788-64-9)
- Ethyl 2-(4-(2-hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)thiazole-4-carboxylate (CAS 937604-28-9)
- 4-Bromo-5-methoxypyridine-2-sulfonyl chloride (CAS 1807214-64-7)
- Tert-butyl 2-(3-chlorobenzoyl)hydrazine-1-carboxylate (CAS 351892-45-0)
- Indacaterol Impurity 72 (CAS CATO-C4X-150072)
- Pentyl Acrylate (CAS 2998-23-4)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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