2-Chloro-N-(4-methoxy-2-nitrophenyl)acetamide CAS 3223-77-6
| CAS No. | 3223-77-6 |
| Molecular Formula | C9H9ClN2O4 |
| Molecular Weight | 244.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-Chloro-N-(4-methoxy-2-nitrophenyl)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-Chloro-N-(4-methoxy-2-nitrophenyl)acetamide (CAS 3223-77-6), molecular formula C9H9ClN2O4 and molecular weight 244.63 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-Chloro-N-(4-methoxy-2-nitrophenyl)acetamide (C9H9ClN2O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 244.63 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H9ClN2O4 |
| Molecular Weight | 244.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- N-(5-Chloro-2-(hydroxymethyl)-3-nitrophenyl)acetamide (CAS 1000342-63-1)
- 2-Chloro-N-[(2-hydroxy-5-nitrophenyl)methyl]acetamide (CAS 110952-49-3)
- 2-Chloro-N-methoxy-N-methyl-5-nitrobenzamide (CAS 1184366-24-2)
- (2-Chloro-4-formyl-6-methoxyphenoxy)acetic acid (CAS 123022-07-1)
- Ethyl 2-(3-chloro-5-nitropyridin-4-yl)acetate (CAS 1363380-74-8)
- Methyl 2-chloro-4-(methylamino)-5-nitrobenzoate (CAS 1380836-76-9)
- 3-CHloro-n-methoxy-n-methyl-5-nitrobenzamide (CAS 1487773-85-2)
- N-(5-Chloro-4-methoxy-2-nitrophenyl)acetamide (CAS 160088-53-9)
Recommended Standards
- 2-Chloro-N-(4-hydroxy-3-nitrobenzyl)acetamide (CAS 300707-85-1)
- 3-Amino-3-(2-chloro-5-nitrophenyl)propanoic acid (CAS 282524-74-7)
- 2-Chloro-n-(2-methoxy-5-nitrophenyl)acetamide (CAS 58795-63-4)
- 3-Amino-3-(4-chloro-3-nitrophenyl)propionic Acid (CAS 682804-60-0)
- 2-phenylquinolin-4-amine hydrochloride (CAS 65197-47-9)
- 1-[2-Chloro-4-(methylsulfonyl)phenyl]-3-methylpiperazine (CAS 942474-68-2)
- 4-(Aminomethyl)-3-bromobenzoic acid (CAS 96053-37-1)
- Octadecenylsuccinic Anhydride (mixture of isomers) (CAS 19024-74-9)
- 2-(4-Chlorophenyl)quinoline-4-carbonyl chloride (CAS 854864-03-2)
- 2-(2-Hydroxyphenyl)thiazole-4-carboxylic acid (CAS 27501-91-3)
- Ethyl 2-(2-formyl-6-methoxyphenoxy)acetate (CAS 70076-67-4)
- 6-Bromo-4-(difluoromethyl)-5-methoxynicotinic acid (CAS 1805351-77-2)
- 4-Decyl-1-tetradecanol (CAS 123613-13-8)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
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