2-(6-Bromo-4-oxo-3,4-dihydroquinazolin-2-yl)-3-(5-chloro-2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile CAS 328033-56-3
| CAS No. | 328033-56-3 |
| Molecular Formula | C16H9BrClN5O2S |
| Molecular Weight | 450.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 450.70 g/mol gives 2-(6-Bromo-4-oxo-3,4-dihydroquinazolin-2-yl)-3-(5-chloro-2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(6-Bromo-4-oxo-3,4-dihydroquinazolin-2-yl)-3-(5-chloro-2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile (CAS 328033-56-3) is a high-purity analytical reference standard with the molecular formula C16H9BrClN5O2S and a molecular weight of 450.70 g/mol.
The molecular framework of 2-(6-Bromo-4-oxo-3,4-dihydroquinazolin-2-yl)-3-(5-chloro-2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile (C16H9BrClN5O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-(6-Bromo-4-oxo-3,4-dihydroquinazolin-2-yl)-3-(5-chloro-2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H9BrClN5O2S |
| Molecular Weight | 450.70 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Bromo Standards
- 2-Bromo-4-(2-methylphenyl)-thiazaole, 97% (CAS 1188124-86-8)
- 4-Bromo-3,3,4,4-tetrafluorobutyl (2,2,3,3,4,4,4-heptafluorobutyl) carbonate (CAS 1980085-53-7)
- N-(4'-Bromo-4-biphenylyl)-N-phenyl-1-naphthylamine (CAS 352359-42-3)
- N-(2-(3-bromo-2-hydroxynaphthalen-1-yl)-4-methoxy-3,5-dimethylphenyl)methanesulfonamide (CAS 1832514-09-6)
- N-(2-(6-bromo-2-hydroxynaphthalen-1-yl)-4-methoxy-3,5-dimethylphenyl)methanesulfonamide (CAS 1832514-10-9)
- N-(2-(7-bromo-2-hydroxynaphthalen-1-yl)-4-methoxy-3,5-dimethylphenyl)methanesulfonamide (CAS 1832514-12-1)
- 2-(6-Bromo-4-oxoquinazolin-3(4H)-yl)-N-(4-phenoxyphenyl)acetamide (CAS 853318-75-9)
- Ethyl 4-(2-(2-bromo-6-ethoxy-4-formylphenoxy)acetamido)benzoate (CAS 832673-83-3)
Recommended Standards
- N,N'-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide) (CAS 124172-53-8)
- 4,4-Dinonylazoxybenzene (CAS 37592-91-9)
- Diisodecyl Phthalate-d4 (CAS 1346604-79-2)
- Vitamin K1 (CAS 81818-54-4)
- tert-Butyl (S)-(4,4-difluoropyrrolidin-3-yl)carbamate (CAS 2166050-86-6)
- 2-(3-((Benzyl(cyclopropyl)amino)methyl)pyrrolidin-1-yl)acetic acid (CAS 1353984-92-5)
- Cyclopropanecarboxylic acid, 2,5-dioxo-1-pyrrolidinyl ester (CAS 70074-39-4)
- Benzyl-(6-methyl-pyridin-2-ylmethyl)-aminehydrochloride (CAS 1185293-34-8)
- (3-(1H-Pyrrol-1-yl)phenyl)boronic acid (CAS 1311132-65-6)
- 3-Iodo-7-methyl-1,6,7,8-tetrahydro-4H-dipyrrolo[1,2-a:2',3'-d]pyrimidin-4-one (CAS 2360625-87-0)
- 1-Thia-4-azaspiro[4.6]Undecane hydrochloride (CAS 875-11-6)
- 3-Bromo-2-cyano-5-hydroxybenzoic acid (CAS 1804381-52-9)
- 4-Bromobenzoyl cyanide (CAS 6048-21-1)
- Glucagon-like peptide 2 (CAS 89750-15-2)
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