Varenicline Impurity 66 HCI CAS 328055-88-5
| CAS No. | 328055-88-5 |
| Molecular Formula | C13H15N3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Varenicline Impurity 66 HCI (CAS 328055-88-5), a pharmacopoeial impurity reference standard (molecular formula C13H15N3HCl, MW 249.74 g/mol) used for the identification and quantification of trace impurities in APIs.
Varenicline Impurity 66 HCI (C13H15N3HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H15N3 HCl |
| Molecular Weight | 249.74 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Varenicline Standards
- Varenicline Impurity 28 (CAS 1026685-55-1)
- Varenicline Impurity 6 (CAS 116601-09-3)
- Varenicline Impurity 22 (CAS 1213781-59-9)
- Varenicline Impurity 31 (CAS 1333145-89-3)
- Varenicline Impurity 16 (CAS 1337563-47-9)
- Varenicline Impurity 70 (CAS 1337563-47-9 (free base))
- Varenicline Impurity 23 (CAS 1350219-74-7)
- Varenicline-d4 (CAS 2183239-01-0)
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- 2,4-Dichloro-N-cyclopropylpyrimidine-5-carboxamide (CAS 1017464-37-7)
- 3-(3-Chlorophenyl)-3-methylbutanoic acid (CAS 4094-61-5)
- Ethyl (E)-(3-(4-benzylpiperazin-1-yl)-2-cyanoacryloyl)carbamate (CAS 477853-55-7)
- 7,8-Dihydroxy-6-nitro-2-oxo-2H-chromene-3-carboxylic acid (CAS 388118-89-6)
- 2-Chloro-3-cyclopropoxypyridine (CAS 1243368-75-3)
- (R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide (CAS 439081-17-1)
- D-Pro31-Tirzepatide (CAS CATO-CPTD788905)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com