1-(3-Fluorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline CAS 331852-85-8
| CAS No. | 331852-85-8 |
| Molecular Formula | C17H18FNO2 |
| Molecular Weight | 287.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(3-Fluorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline.
1-(3-Fluorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (CAS 331852-85-8) is a high-purity analytical reference standard with the molecular formula C17H18FNO2 and a molecular weight of 287.33 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 1-(3-Fluorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 287.33 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(3-Fluorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H18FNO2 |
| Molecular Weight | 287.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorophenyl Standards
- Benzyl (2-(4-fluorophenyl)propan-2-yl)carbamate (CAS 1403483-60-2)
- (3-(4-Fluorophenyl)azepan-1-yl)(furan-2-yl)methanone (CAS 1797604-67-1)
- 1-(2-Fluorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (CAS 412958-64-6)
- 1-(4-fluorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (CAS 55507-14-7)
- 4-(4-(4-Fluorophenyl)piperazin-1-yl)-6-methylpyrimidin-2-amine (CAS 873839-03-3)
- 4-(4-Fluorophenyl)-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide (CAS 1251685-98-9)
- Methyl 4-(4-fluorophenyl)thieno[3,2-c]pyridine-6-carboxylate (CAS 1344688-13-6)
- Methyl 4-(2-fluorophenyl)thieno[3,2-c]pyridine-6-carboxylate (CAS 1344704-45-5)
Recommended Standards
- (E)-3-ethoxy-2-(naphthalen-2-ylsulfonyl)acrylonitrile (CAS 32083-61-7)
- 1-Benzyl-1H-benzo[c][1,2]thiazin-4(3H)-one 2,2-dioxide (CAS 31846-95-4)
- (1-(Phenylsulfonyl)-1H-indol-3-yl)methanol (CAS 89241-33-8)
- 1-tert-butoxycarbonyl-5-fluoro-indoline-2-carboxylic acid (CAS 2306260-73-9)
- 6-(2-Methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (CAS 1204296-71-8)
- N-(1,1-dioxidothietan-3-yl)azetidine-3-carboxamide (CAS 1854209-88-3)
- 2-Chloro-N-(2-(4-fluorophenoxy)ethyl)benzamide (CAS 1105209-89-9)
- methyl 5-bromo-4-chloro-2-nitrobenzoate (CAS 1820703-50-1)
- 6-Methylbenzofuran-3-acetic Acid (CAS 142917-39-3)
- Palbociclib Impurity 55 (CAS 1430196-98-7)
- 4-((4,6-Dimethoxypyrimidin-2-yl)oxy)-2-methylaniline (CAS 866154-85-0)
- N-Isopropylazetidin-3-amine (CAS 888069-49-6)
- 3-Bromo-6-methylpyrazolo[1,5-a]pyridine (CAS 1824301-67-8)
- Anti-Inflammatory Peptide 1 (CAS 118850-71-8)
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