N-(5-chloro-2-methylphenyl)-2-((5-((4-methoxyphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide CAS 332912-74-0
| CAS No. | 332912-74-0 |
| Molecular Formula | C25H23ClN4O3S |
| Molecular Weight | 494.99 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 494.99 g/mol gives N-(5-chloro-2-methylphenyl)-2-((5-((4-methoxyphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N-(5-chloro-2-methylphenyl)-2-((5-((4-methoxyphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332912-74-0), molecular formula C25H23ClN4O3S and molecular weight 494.99 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(5-chloro-2-methylphenyl)-2-((5-((4-methoxyphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (C25H23ClN4O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(5-chloro-2-methylphenyl)-2-((5-((4-methoxyphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H23ClN4O3S |
| Molecular Weight | 494.99 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related N Standards
- N-(3-chloro-2-methylphenyl)-2-((5-((4-methoxyphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332912-76-2)
- 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic Acid (CAS 1233332-37-0)
- N-(5-Chloro-2-methoxyphenyl)-2-(10-(morpholine-4-carbonyl)-3,4-dihydrobenzo[b][1,6]naphthyridin-2(1H)-yl)acetamide (CAS 1228168-21-5)
- 1-(((4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)sulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]Heptan-2-one oxime (CAS 1025625-73-3)
- N-(4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)phenyl)naphthalene-2-sulfonamide (CAS 1023540-33-1)
- Ethyl 4-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (CAS 860789-41-9)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-[(1E)-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]piperidine-4-carbohydrazide (CAS 477711-40-3)
- 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-1-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (CAS 338399-24-9)
Recommended Standards
- EGF816 (CAS 1508250-71-2)
- Ethyl 2-{2-[(4-chlorophenyl)methanesulfonyl]-4,5-diphenyl-1H-imidazol-1-yl}acetate (CAS 866038-68-8)
- Fluocortolone Impurity 5 (CAS CATO-C4X-22305)
- Ethyl 2-(2-((2-chlorobenzyl)sulfonyl)-4,5-diphenyl-1H-imidazol-1-yl)acetate (CAS 339277-76-8)
- tert-Butyl (trans-4-(cyclobutylamino)cyclohexyl)carbamate (CAS 1286275-75-9)
- (2,5-Dimethyltetrahydro-2H-pyran-2-yl)methanol (CAS 54004-46-5)
- 5-Methoxy-2-nitro-4-((tetrahydrofuran-2-yl)methoxy)benzoic acid (CAS 1096877-81-4)
- (E)-4-(2-nitrostyryl)-6-(trifluoromethyl)-2,3-dihydrothieno[3,2-c]quinoline (CAS 865658-29-3)
- (3S,4aR,8aR)-decahydroisoquinoline-3-carboxylic acid (CAS 136465-84-4)
- 6-[2-(2,6-dioxo-3-piperidyl)-3-oxo-isoindolin-5-yl]hexanal (CAS 2762039-49-4)
- 1,1-Dibenzylguanidine hydrochloride (CAS 329-39-5)
- 1-(2-Nitro-4-(trifluoromethyl)phenyl)pyrrolidine (CAS 40832-82-4)
- N-(5-bromothieno[2,3-d]pyrimidin-4-yl)-4-chlorobenzenesulfonamide (CAS 2007921-12-0)
- Semaglutide Impurity 152 xTFA (CAS CATO-C4X-2226152)
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