Methyl 5-((3-chloro-4-methylphenyl)carbamoyl)-2-(4-chlorobenzamido)-4-methylthiophene-3-carboxylate CAS 332928-33-3
| CAS No. | 332928-33-3 |
| Molecular Formula | C22H18Cl2N2O4S |
| Molecular Weight | 477.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methyl 5-((3-chloro-4-methylphenyl)carbamoyl)-2-(4-chlorobenzamido)-4-methylthiophene-3-carboxylate is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Methyl 5-((3-chloro-4-methylphenyl)carbamoyl)-2-(4-chlorobenzamido)-4-methylthiophene-3-carboxylate (CAS 332928-33-3) is a high-purity analytical reference standard with the molecular formula C22H18Cl2N2O4S and a molecular weight of 477.36 g/mol.
Structurally, Methyl 5-((3-chloro-4-methylphenyl)carbamoyl)-2-(4-chlorobenzamido)-4-methylthiophene-3-carboxylate (C22H18Cl2N2O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 477.36 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl 5-((3-chloro-4-methylphenyl)carbamoyl)-2-(4-chlorobenzamido)-4-methylthiophene-3-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H18Cl2N2O4S |
| Molecular Weight | 477.36 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Methyl Standards
- 3-{3-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-1-(4-chlorobenzenesulfonyl)-1H-pyrazole (CAS 477712-73-5)
- N-(4-chloro-2-methylphenyl)-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)benzenesulfonamide (CAS 338775-40-9)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(4-chlorophenyl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 303151-99-7)
- 3-Chloro-5-(3-chlorophenyl)-2-(3,4-dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (CAS 691868-55-0)
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(2,4-dichlorobenzoyl)-1H-pyrrole-2-carbohydrazide (CAS 338403-48-8)
- 2-(3-Chloro-2-oxopropyl)-3-(1H-indol-3-yl)-6-iodoquinazolin-4(3H)-one (CAS 655250-53-6)
- (2E)-3-[(4-Chloro-3-nitrophenyl)amino]-1-{3-[(2,4-dichlorophenyl)methoxy]phenyl}prop-2-en-1-one (CAS 478040-27-6)
- N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide (CAS 1112980-86-5)
Recommended Standards
- Methyl 2-(3,4-dichlorobenzamido)-4-methyl-5-(m-tolylcarbamoyl)thiophene-3-carboxylate (CAS 335409-72-8)
- N-(3-Bromophenyl)-2-(N-(1-isopropyl-1H-pyrazol-5-yl)phenylsulfonamido)acetamide (CAS 957041-45-1)
- 2-((N-(2,4-dichloro-5-(2-methoxyethoxy)phenyl)-4-methoxyphenyl)sulfonamido)-N-methylacetamide (CAS 338967-86-5)
- Daraxonrasib Impurity 4 (CAS CATO-C4X-35184)
- 7-Fluoro-8-nitroquinoline-2-carbaldehyde (CAS 1420799-84-3)
- 2-(Isopropyl(1-(pyrazin-2-yl)ethyl)amino)acetic acid (CAS 1353943-67-5)
- 1-(2-(2-Bromophenoxy)ethyl)-4-methylpiperidine (CAS 401482-31-3)
- 3-(2-Fluorophenyl)-5-((1-(styrylsulfonyl)piperidin-3-yl)methyl)-1,2,4-oxadiazole (CAS 1706503-50-5)
- Methyl 1-ethyl-1H-pyrazole-5-carboxylate (CAS 119458-46-7)
- 3-(5-Bromo-2-methoxyphenyl)-2-oxopropanoic acid (CAS 858276-17-2)
- 6-(Trifluoromethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 189940-04-3)
- 2-Chloro-1-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2,2-difluoroethan-1-one (CAS 1823183-01-2)
- 1-(6-Amino-2-methoxyphenyl)ethanone (CAS 33844-23-4)
- Semaglutide impurity 86 (CAS CATO-C4X-152686)
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