Methyl N-(5-chloro-2-methylphenyl)-N-(methylsulfonyl)glycinate CAS 333321-67-8
| CAS No. | 333321-67-8 |
| Molecular Formula | C11H14ClNO4S |
| Molecular Weight | 291.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Methyl N-(5-chloro-2-methylphenyl)-N-(methylsulfonyl)glycinate (CAS 333321-67-8), molecular formula C11H14ClNO4S and molecular weight 291.75 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl N-(5-chloro-2-methylphenyl)-N-(methylsulfonyl)glycinate (C11H14ClNO4S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H14ClNO4S |
| Molecular Weight | 291.75 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Recommended Standards
- Methyl N-(4-chloro-2-methylphenyl)-N-(methylsulfonyl)glycinate (CAS 333320-38-0)
- tert-Butyl (3-(chlorosulfonyl)phenyl)carbamate (CAS 269747-26-4)
- Methyl N-(3-chloro-4-methylphenyl)-N-(methylsulfonyl)glycinate (CAS 363178-68-1)
- tert-Butyl (4-(chlorosulfonyl)phenyl)carbamate (CAS 269747-25-3)
- 3-Piperidin-4-ylmethyl-isoquinoline dihydrochloride (CAS 1187928-64-8)
- Ethyl 2-(5-Nitro-3-indolyl)-2-oxoacetate (CAS 91974-31-1)
- Isoquinoline-6-boronic Acid Hydrochloride (CAS 1236031-63-2)
- 2-(1-cyano-1-methylethyl)-6-fluorobenzonitrile (CAS 1314783-56-6)
- tert-Butyl 3-(2,3-difluoro-4-methylphenyl)-3-hydroxyazetidine-1-carboxylate (CAS 1697803-56-7)
- Safinamide Impurity 24 (CAS CATO-C4X-159024)
- 4-(5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-amine (CAS 312628-68-5)
- 3-Difluoromethoxy-2-fluoroisonicotinic acid (CAS 1806376-43-1)
- tert-Butyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate (CAS 1006876-29-4)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
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