3-((2-(5-Nitrothiophen-2-yl)quinazolin-4-yl)amino)propane-1,2-diol CAS 33372-40-6
| CAS No. | 33372-40-6 |
| Molecular Formula | C15H14N4O4S |
| Molecular Weight | 346.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-((2-(5-Nitrothiophen-2-yl)quinazolin-4-yl)amino)propane-1,2-diol (CAS 33372-40-6) is a high-purity analytical reference standard with the molecular formula C15H14N4O4S and a molecular weight of 346.36 g/mol.
3-((2-(5-Nitrothiophen-2-yl)quinazolin-4-yl)amino)propane-1,2-diol (C15H14N4O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H14N4O4S |
| Molecular Weight | 346.36 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Nitrothiophen Standards
- 2,2'-((2-(5-Nitrothiophen-2-yl)quinazolin-4-yl)azanediyl)diethanol (CAS 33372-39-3)
- 2-((2-(5-Nitrothiophen-2-yl)quinazolin-4-yl)amino)ethanol (CAS 33389-36-5)
- N-((5-Nitrothiophen-3-yl)methylene)-3-(thiophen-2-yl)isoxazol-5-amine (CAS 37853-26-2)
- (Z)-4-((5-Nitrothiophen-2-yl)methylene)-2-phenyloxazol-5(4H)-one (CAS 89035-35-8)
- 3-Methyl-2-(2-(5-nitrothiophen-2-yl)vinyl)benzofuran (CAS 89266-62-6)
- Ethyl 4-(5-nitrothiophen-2-yl)piperazine-1-carboxylate (CAS 706767-17-1)
- 2-(5-Nitrothiophen-2-yl)-2,3-dihydroquinazolin-4(1H)-one (CAS 33389-33-2)
- 2-(2-(5-Nitrothiophen-2-yl)vinyl)benzofuran (CAS 89266-48-8)
Recommended Standards
- 3-((1-Benzyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl)thio)propanoic acid (CAS 4829-90-7)
- 3-(Triphenyl-l5-phosphanylidene)dihydrofuran-2(3H)-one (CAS 34932-07-5)
- 2-[4-(2-Carboxypropoxy)-3-cyanophenyl]-4-methyl-5-thiazolecarboxylic Acid (CAS 407582-49-4)
- 4-((4-Methoxyphenyl)sulfonyl)-2-methylbenzo[f][1,3,4]oxadiazepin-5(4H)-one (CAS 861210-87-9)
- 1-(Methoxymethyl)pyrrole (CAS 76322-78-6)
- 3-Bromo-5-bromomethyl-isoxazole (CAS 88982-28-9)
- Ethyl (2E,4E)-5-(dimethylamino)-2-(2,2,2-trifluoroacetyl)penta-2,4-dienoate (CAS 1146961-22-9)
- (R)-5-chloro-6-fluoro-2,3-dihydro-1H-inden-1-amine (CAS 1259923-08-4)
- 6-Chloro-N-(4-pyridinylmethyl)-2-pyridinamine (CAS 1220018-69-8)
- 2-(tert-Butyl)-4,6-diphenylpyrylium tetrafluoroborate (CAS 7594-23-2)
- 1-(2-(4-Methyl-6-morpholinopyridin-3-yl)pyrrolidin-1-yl)ethanone (CAS 1352525-79-1)
- 3-Amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide (CAS 639859-24-8)
- (2S)-4-Methyl-2-morpholinemethanamine Dihydrochloride (CAS 137524-88-0)
- Pancreatic Polypeptide (31-36), amide, human (CAS 74012-13-8)
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