2,3-Difluoro-5-iodobenzoic acid CAS 333780-74-8
| CAS No. | 333780-74-8 |
| Molecular Formula | C7H3F2IO2 |
| Molecular Weight | 284.00 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,3-Difluoro-5-iodobenzoic acid (CAS 333780-74-8), molecular formula C7H3F2IO2 and molecular weight 284.00 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/iodine substitution, an aromatic ring system, 2,3-Difluoro-5-iodobenzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 284.00 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3F2IO2 |
| Molecular Weight | 284.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/I-containing |
Related Difluoro Standards
- 2,6-Difluoro-4-iodobenzoic acid (CAS 1160575-07-4)
- 4,5-Difluoro-2-iodobenzoic Acid (CAS 130137-05-2)
- 2,4-Difluoro-5-iodobenzoic acid (CAS 161531-51-7)
- 2,2-Difluoro-4-iodobenzo[d][1,3]dioxole (CAS 531508-54-0)
- 2,2-Difluoro-5-iodobenzo[d][1,3]dioxole (CAS 663934-17-6)
- 2,3-Difluoro-4-iodobenzoic acid (CAS 501433-05-2)
- 2,3-Difluoro-6-iodobenzoic acid (CAS 333780-75-9)
- 2,5-difluoro-4-iodobenzoic acid (CAS 501433-01-8)
Recommended Standards
- 2,6-Difluoro-3-iodobenzoic Acid (CAS 229178-74-9)
- 3,5-Difluoro-4-iodobenzoic acid (CAS 658-06-0)
- 3,6-Difluoro-2-iodobenzoic acid (CAS 501432-98-0)
- 2,5-Dibromo-3-propylthiophene (CAS 1187577-36-1)
- (DHQD)2Pyr (CAS 149725-81-5)
- Tert-butyl 5-(hydroxymethyl)-1H-indazole-1-carboxylate (CAS 1245648-89-8)
- 5-Bromo-1-(4-fluorobenzyl)-1H-pyrazole (CAS 1057383-80-8)
- 3-{1-[2-(4-chlorophenoxy)acetyl]piperidin-4-yl}-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775396-54-7)
- 2-(chloromethyl)-4-(trifluoromethyl)pyridine (CAS 215867-87-1)
- (Z)-4-(4-methoxybenzylidene)-2-methyloxazol-5(4h)-one (CAS 71198-72-6)
- Dronedarone Impurity 48 (CAS CATO-C4X-109248)
- 2,5-Bis(2,4-dichlorophenyl)-1,3,4-oxadiazole (CAS 2492-00-4)
- 2-Hydroxy-N-methoxyquinoline-4-carboxamide (CAS 1258676-43-5)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
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