1-(Cyclopropylmethyl)-4-phenylquinazolin-2(1H)-one CAS 33453-22-4

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(Cyclopropylmethyl)-4-phenylquinazolin-2(1H)-one.

1-(Cyclopropylmethyl)-4-phenylquinazolin-2(1H)-one (CAS 33453-22-4) is a high-purity analytical reference standard with the molecular formula C18H16N2O and a molecular weight of 276.33 g/mol.

Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, 1-(Cyclopropylmethyl)-4-phenylquinazolin-2(1H)-one is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 276.33 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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