3-(4,5-Bis(4-chlorophenyl)oxazol-2-yl)propanoic acid CAS 33466-16-9
| CAS No. | 33466-16-9 |
| Molecular Formula | C18H13Cl2NO3 |
| Molecular Weight | 362.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
3-(4,5-Bis(4-chlorophenyl)oxazol-2-yl)propanoic acid (CAS 33466-16-9), molecular formula C18H13Cl2NO3 and molecular weight 362.21 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(4,5-Bis(4-chlorophenyl)oxazol-2-yl)propanoic acid (C18H13Cl2NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H13Cl2NO3 |
| Molecular Weight | 362.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bis Standards
- 3,3-Bis-[(4-chlorophenyl)methyl]-piperidine-1H-2,4-dione (CAS 1706445-92-2)
- 4-Chlorophenyl (E)-3-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)acrylate (CAS 246022-39-9)
- N-(3-chlorophenyl)-2-((2,3,4,5,6-pentamethylbenzyl)thio)acetamide (CAS 329079-23-4)
- N-(3-Chlorophenyl)-2-[(2-methylphenyl)imino]-1,3-thiazolane-3-carbothioamide (CAS 73316-76-4)
- (4-Chlorophenyl)(4-hydroxy-4-((phenylthio)methyl)piperidin-1-yl)methanone (CAS 478248-09-8)
- 2-(4-Chlorophenyl)-3-[(4-methylphenyl)sulfanyl]quinoline (CAS 477867-86-0)
- 2-[(3-Chlorophenyl)sulfanyl]-3-(4-methylphenyl)quinoline (CAS 339102-50-0)
- 2-[(4-Chlorophenyl)sulfanyl]-3-(4-methylphenyl)quinoline (CAS 339102-42-0)
Recommended Standards
- 3-(2,6-Dichlorophenyl)-5-methyl-N-(pyridin-4-ylmethyl)isoxazole-4-carboxamide (CAS 349134-85-6)
- 3,4-Dichloro-N-((2,4-diaminoquinazolin-6-yl)methyl)benzamide (CAS 55096-65-6)
- 2-hydroxyethyl 2-hydroxypropanoate (CAS 29671-83-8)
- 5-(3-Chloro-4-methoxyphenyl)-N-(2-chlorophenyl)furan-2-carboxamide (CAS 853333-69-4)
- 4-Methoxy-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)aniline (CAS 1454653-66-7)
- 2-(Azetidin-1-yl)-5-bromoaniline (CAS 1849343-62-9)
- 1-[(3,4-Dichlorophenyl)methyl]-6-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 337919-92-3)
- 7-(Benzyloxy)-4-methyl-2-oxo-2H-chromene-3-carbonitrile (CAS 331651-91-3)
- Ethyl 2-(5-phenyl-2H-tetrazol-2-yl)acetate (CAS 21054-65-9)
- Methyl 3-(2,5-difluorophenyl)benzoate (CAS 1820641-77-7)
- Letermovir Impurity 120 (CAS CATO-C4X-2915120)
- 2,4,6,7-Tetrahydrospiro[indazole-5,2'-[1,3]dioxolane] hydrochloride (CAS 1160245-61-3)
- 2-(4-Formyl-6-(methoxycarbonyl)pyridin-2-yl)acetic acid (CAS 1393530-59-0)
- Semaglutide impurity 38 (CAS CATO-C4X-222638)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com