N-(4-Fluorophenyl)-3-nitrobenzamide CAS 33489-69-9
| CAS No. | 33489-69-9 |
| Molecular Formula | C13H9FN2O3 |
| Molecular Weight | 260.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
N-(4-Fluorophenyl)-3-nitrobenzamide (CAS 33489-69-9) is a high-purity analytical reference standard with the molecular formula C13H9FN2O3 and a molecular weight of 260.22 g/mol.
The molecular framework of N-(4-Fluorophenyl)-3-nitrobenzamide (C13H9FN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), N-(4-Fluorophenyl)-3-nitrobenzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9FN2O3 |
| Molecular Weight | 260.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-(3-fluorophenyl)-3-nitrobenzamide (CAS 167565-76-6)
- N-(3-FLuorophenyl)-4-nitrobenzamide (CAS 167565-78-8)
- 2-{[(4-Fluorophenyl)imino]methyl}-4-nitrophenol (CAS 316131-10-9)
- N-(2-fluorophenyl)-3-nitrobenzamide (CAS 198879-93-5)
- N-(2-Fluorophenyl)-4-nitrobenzamide (CAS 303990-29-6)
- n-(2-Fluorophenyl)-4-nitrobenzamide (CAS 5336-54-9)
- N-(4-Fluorophenyl)-4-nitrobenzamide (CAS 347-81-9)
- (Z)-3-(3-fluorophenyl)-3-(4-fluorophenyl)acrylic acid (CAS 1017141-10-4)
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