3,3,3-Trifluoro-2-hydroxy-2-methylpropanenitrile CAS 335-08-0
| CAS No. | 335-08-0 |
| Molecular Formula | C4H4F3NO |
| Molecular Weight | 139.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3,3,3-Trifluoro-2-hydroxy-2-methylpropanenitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3,3,3-Trifluoro-2-hydroxy-2-methylpropanenitrile (CAS 335-08-0), molecular formula C4H4F3NO and molecular weight 139.08 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3,3,3-Trifluoro-2-hydroxy-2-methylpropanenitrile (C4H4F3NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C4H4F3NO |
| Molecular Weight | 139.08 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoro Standards
- 1,1,1-trifluoro-3-isocyanatopropane (CAS 406-97-3)
- 4,4,4-trifluoro-3-hydroxybutanenitrile (CAS 57165-85-2)
- (2E)-4,4,4-Trifluoro-2-butenoic acid (CAS 406-94-0)
- 4,4,4-Trifluoro-3-oxobutanal (CAS 70817-53-7)
- 1,1,1-Trifluoro-3-methylbutan-2-one (CAS 382-03-6)
- 2,2,2-Trifluoro-N,N-dimethylacetimidamide (CAS 684-09-3)
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Recommended Standards
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- 4-(Trifluoromethyl)azetidin-2-one (CAS 88968-81-4)
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- Favipiravir Impurity 17 (CAS 1137606-76-8)
- 4,7-Dichloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one (CAS 2252403-83-9)
- trans-4-Methoxypiperidin-3-ol (CAS 1612172-92-5)
- Methyl 2-(1,2,3,4-tetrahydroisoquinolin-4-yl)acetate hydrochloride (CAS 16261-33-9)
- [S(R)]-N-[(S)-[2-(Diphenylphosphino)-4,5-dimethoxyphenyl)](4-methoxyphenyl)methyl]-2-methyl-2-propanesulfinamide (CAS 2417456-70-1)
- 4,5,7-Trifluoro-1H-indole-3-carbaldehyde (CAS 467457-04-1)
- 5,6,7,8-Tetrahydroquinolin-6-amine (CAS 477532-03-9)
- 4'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-3,5-dicarboxylicacid (CAS 1159595-96-6)
- 2-(2-Bromo-6-methylpyridin-4-yl)ethan-1-amine (CAS 1393576-11-8)
- 9-Butyl-1,2,3,4,5,6,7,8-octahydroacridin-4-ol (CAS 99922-91-5)
- Tirzepatide Impurity 51 (CAS CATO-C4X-324051)
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