1-Cyclopropyl-4-(trifluoromethyl)benzene CAS 33598-75-3
| CAS No. | 33598-75-3 |
| Molecular Formula | C10H9F3 |
| Molecular Weight | 186.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Cyclopropyl-4-(trifluoromethyl)benzene.
1-Cyclopropyl-4-(trifluoromethyl)benzene (CAS 33598-75-3), molecular formula C10H9F3 and molecular weight 186.17 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-Cyclopropyl-4-(trifluoromethyl)benzene (C10H9F3) is characterized by fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9F3 |
| Molecular Weight | 186.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | F-containing |
Related Cyclopropyl Standards
- 2-Cyclopropyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (CAS 1027785-18-7)
- 1-Cyclopropyl-1H-benzo[d]imidazole-2-carbaldehyde (CAS 118500-36-0)
- 3-(5-Cyclopropyl-1H-1,2,4-triazol-3-yl)pyridine (CAS 1211439-70-1)
- 1-Cyclopropyl-4,4-dimethoxybutane-1,3-dione (CAS 1479222-39-3)
- 1-Cyclopropyl-1H-indazole-3-carbaldehyde (CAS 1924188-82-8)
- 1-Cyclopropyl-1H-indazole-6-carbaldehyde (CAS 1924188-86-2)
- 1-Cyclopropyl-1H-indazole-5-carbaldehyde (CAS 1935241-89-6)
- N-Cyclopropyl-2-ethynylisonicotinamide (CAS 1956370-83-4)
Recommended Standards
- 1-Cyanoindolizine-2-carboxylic acid (CAS 852562-13-1)
- 1H-Imidazo[4,5-g]quinoxalin-2(3H)-one (CAS 25808-68-8)
- 1,8-Naphthyridine-2,7-dicarbaldehyde (CAS 65896-28-8)
- 1-Isopropenyl-4-(trifluoromethyl)benzene (CAS 55186-75-9)
- 3-(3-Fluorophenyl)-1,2,4-oxadiazole-5-thiol (CAS 1342386-00-8)
- 6-Chloro-4-methoxy-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (CAS 1190322-45-2)
- 3-Bromo-4-(trifluoromethoxy)phenylisocyanate (CAS 685859-17-0)
- Propargyl-PEG12-amine (CAS 2264091-73-6)
- 2-Methyl Nornicotine (CAS 64114-19-8)
- N-(4-(5-(Furan-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)benzamide (CAS 648430-60-8)
- Benzyl 8-amino-2-azaspiro[4.5]Decane-2-carboxylate (CAS 1420825-27-9)
- 4’-Fluoro-2-(4-fluorophenyl)acetophenone (CAS 366-68-7)
- 1-Benzyl-4-hydroxyquinolin-2(1H)-one (CAS 105024-96-2)
- D-[Ser]8-Semaglutide (CAS CATO-C4X-2226207)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com