3-(2-Methoxyphenyl)-2-methylacrylic acid CAS 3368-15-8

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(2-Methoxyphenyl)-2-methylacrylic acid.

3-(2-Methoxyphenyl)-2-methylacrylic acid (CAS 3368-15-8), molecular formula C11H12O3 and molecular weight 192.21 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 3-(2-Methoxyphenyl)-2-methylacrylic acid (C11H12O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 3-(2-Methoxyphenyl)-2-methylacrylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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