3-Amino-N-(2-methoxyphenyl)-4-(4-methoxyphenyl)-6-(p-tolyl)thieno[2,3-b]pyridine-2-carboxamide CAS 337498-31-4
| CAS No. | 337498-31-4 |
| Molecular Formula | C29H25N3O3S |
| Molecular Weight | 495.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Amino-N-(2-methoxyphenyl)-4-(4-methoxyphenyl)-6-(p-tolyl)thieno[2,3-b]pyridine-2-carboxamide.
3-Amino-N-(2-methoxyphenyl)-4-(4-methoxyphenyl)-6-(p-tolyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 337498-31-4) is a high-purity analytical reference standard with the molecular formula C29H25N3O3S and a molecular weight of 495.59 g/mol.
The molecular framework of 3-Amino-N-(2-methoxyphenyl)-4-(4-methoxyphenyl)-6-(p-tolyl)thieno[2,3-b]pyridine-2-carboxamide (C29H25N3O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Amino-N-(2-methoxyphenyl)-4-(4-methoxyphenyl)-6-(p-tolyl)thieno[2,3-b]pyridine-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H25N3O3S |
| Molecular Weight | 495.59 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 3-Amino-N-(2,4-dimethoxyphenyl)-4-phenyl-6-(p-tolyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 443740-48-5)
- 3-Amino-N-(4-ethoxyphenyl)-4-(4-methoxyphenyl)-6-phenylthieno[2,3-b]pyridine-2-carboxamide (CAS 332101-84-5)
- Ethyl 6-amino-5-cyano-2-(((3-cyano-6-phenylpyridin-2-yl)thio)methyl)-4-(pyridin-3-yl)-4H-pyran-3-carboxylate (CAS 340818-10-2)
- (2S)-2-Amino-3-(6-chloro-1H-indol-3-yl)-1-(5-((5-chloro-1H-indol-3-yl)methyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propan-1-one (CAS 2228955-02-8)
- 3-Amino-4-(4-methoxyphenyl)-N-(2-nitrophenyl)-6-phenylthieno[2,3-b]pyridine-2-carboxamide (CAS 332053-72-2)
- Ethyl 6-amino-5-cyano-2-[({5-cyano-[2,4'-bipyridine]-6-yl}sulfanyl)methyl]-4-(pyridin-3-yl)-4H-pyran-3-carboxylate (CAS 313380-23-3)
- N-(6-Amino-1-(4-methoxyphenyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-dibutyl-4-hydroxybenzamide (CAS 176370-47-1)
- N-(6-Amino-1-(4-methoxyphenyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-di-tert-butyl-4-hydroxybenzamide (CAS 176378-81-7)
Recommended Standards
- 2-(4-(1,3-Dioxoisoindolin-2-yl)butanamido)-N-((tetrahydrofuran-2-yl)methyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (CAS 611194-36-6)
- N-(2-Fluorophenyl)-2-((3-(4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 477331-63-8)
- 2-((3-Cyano-6-(4-ethoxyphenyl)-4-phenylpyridin-2-yl)thio)-N-(2-methoxyphenyl)acetamide (CAS 332376-13-3)
- N-(3-Fluorophenyl)-2-((3-(4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 477331-47-8)
- 3940AF 7-Methoxy-2,1,3-benzoxadiazole-4-sulfonyl chloride 944780-94-3 C7H5ClN2O4S (CAS 944780-94-3)
- 1-(3-Carboxyphenyl)-2-thiourea 3-[(aminocarbothioyl)amino]benzoic acid 3-[(Aminocarbonothioyl)amino]benzoic acid 37182-75-5 (CAS 37182-75-5)
- Hydrochlorothiazide Impurity 24 (CAS 1025-75-8)
- 1,1-dioxide-3-oxo-1,2-Benzisothiazole-2(3H)-acetonitrile (CAS 52188-12-2)
- 4-Amino-2-hydroxy-N-methylbenzamide (CAS 170368-39-5)
- Ethyl 4-amino-1-benzylpiperidine-4-carboxylate (CAS 57611-55-9)
- 2-(2-Bromophenyl)-5,5-dimethylmorpholine (CAS 1099679-17-0)
- 5-(2,2,2-Trichloroacetyl)-1h-pyrrole-3-sulfonyl chloride (CAS 867330-05-0)
- 2-((3-Methoxybenzyl)amino)acetamide (CAS 926225-86-7)
- Gly-Neuroendocrine Regulatory Peptide-3 (human, mouse, rat) trifluoroacetate salt (CAS 1815618-19-9)
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