1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid CAS 337919-65-0
| CAS No. | 337919-65-0 |
| Molecular Formula | C12H12ClF3N2O2 |
| Molecular Weight | 308.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid.
1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid (CAS 337919-65-0), molecular formula C12H12ClF3N2O2 and molecular weight 308.68 g/mol, is a CATO reference standard with documented purity and traceability.
1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid (C12H12ClF3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12ClF3N2O2 |
| Molecular Weight | 308.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 1-(6-Chloro-4-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid (CAS 1208081-19-9)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidine-3-carboxylic acid (CAS 874800-69-8)
- 2-Chloro-N-methyl-N-(2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)acetamide (CAS 744227-38-1)
- Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)amino)benzoate (CAS 66427-76-7)
- N-{4-[(6-Chloro-5-nitro-4-pyrimidinyl)oxy]phenyl}acetamide (CAS 860787-22-0)
- 4-Chloro-2-(4-(trifluoromethyl)phenyl)quinazoline (CAS 1041568-57-3)
- 4-Chloro-2-(difluoro(4-fluorophenyl)methyl)quinazoline (CAS 1241914-82-8)
- 6-Chloro-2-(4-(trifluoromethyl)phenyl)quinoxaline (CAS 1391118-27-6)
Recommended Standards
- 2-Trifluoromethanesulfonylbenzene-1-sulfonyl chloride (CAS 77797-87-6)
- 2,4,5-Trichloro-N-octylaniline (CAS 51353-66-3)
- 4-Trifluoromethanesulfonylbenzene-1-sulfonyl chloride (CAS 63647-64-3)
- (Z)-1-(4-chlorophenyl)-2-fluorovinyl diethyl phosphate 1159000-79-9 (CAS 1159000-79-9)
- 1,2,3,8,9-Pentachlorodibenzofuran (CAS 83704-54-5)
- 5-Bromo-4-chloro-2-ethylpyridine (CAS 1353855-49-8)
- 2-(3-Amino-6-methyl-2-oxopyridin-1(2H)-yl)-N-methylacetamide (CAS 1443289-95-9)
- [2-(6,7-Dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-yl)ethyl]amine dihydrochloride (CAS 1609403-51-1)
- (3S)-2-(tert-Butoxycarbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxylic acid (CAS 1272757-15-9)
- 4-Bromo-2,6-dimethylphenol-d8 (Major) (CAS 1142096-13-6)
- 2-(4-Chlorobenzenesulfonyl)-N-[2-(4-chlorobenzenesulfonyl)ethyl]propanamide (CAS 337923-31-6)
- 1-(3-Fluoropyridin-2-yl)-N-methylmethanamine dihydrochloride (CAS 2680616-04-8)
- 7-bromo-2,4-dichloro-8-fluoro-6-iodo-quinazoline (CAS 2241720-34-1)
- Steroidogenesis-Activator Polypeptide (rat) (H-8855.0500) (CAS 108563-23-1)
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