4-(2-Chloro-4-nitrophenoxy)-2-(trifluoromethyl)quinazoline CAS 337924-99-9
| CAS No. | 337924-99-9 |
| Molecular Formula | C15H7ClF3N3O3 |
| Molecular Weight | 369.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(2-Chloro-4-nitrophenoxy)-2-(trifluoromethyl)quinazoline is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(2-Chloro-4-nitrophenoxy)-2-(trifluoromethyl)quinazoline (CAS 337924-99-9), molecular formula C15H7ClF3N3O3 and molecular weight 369.68 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 4-(2-Chloro-4-nitrophenoxy)-2-(trifluoromethyl)quinazoline is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 369.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H7ClF3N3O3 |
| Molecular Weight | 369.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 2-(2-Chloro-5-nitrophenyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (CAS 243644-36-2)
- 3-Chloro-2-(1-(4-nitrophenyl)-1H-1,2,4-triazol-5-yl)-5-(trifluoromethyl)pyridine (CAS 1823183-93-2)
- 6-Chloro-N2,N4-bis(2,4-difluorophenyl)-1,3,5-triazine-2,4-diamine (CAS 2272-38-0)
- 6-Chloro-N-cyclopentyl-5-iodo-2-(methylthio)pyrimidin-4-amine (CAS 917895-52-4)
- 2-Chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline (CAS 1538605-06-9)
- 1-[8-Chloro-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl]piperidin-4-one (CAS 339011-74-4)
- Methyl 4-[2-(4-chloro-2-methylphenoxy)-2,2-difluoroacetamido]benzoate (CAS 339030-58-9)
- (4-(6-Chloro-4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)(phenyl)methanone (CAS 1089330-48-2)
Recommended Standards
- Ethyl (R)-2-chloro-2-(2-nitro-4-(pentafluoro-lambda6-sulfanyl)phenyl)acetate (CAS 1379812-00-6)
- 2,4,6-Tris((trimethylsilyl)ethynyl)-1,3,5-triazine (CAS 155202-89-4)
- Ethyl (R)-2-chloro-2-(2-nitro-5-(pentafluoro-lambda6-sulfanyl)phenyl)acetate (CAS 1379812-17-5)
- 2,4,5-TP-butoxyethyl ester (CAS 19398-13-1)
- Ethyl 6-fluoro-2-methylindole-3-carboxylate (CAS 886362-69-2)
- (1-Cyclopropyl-1H-imidazol-5-yl)methanamine dihydrochloride (CAS 1300713-13-6)
- 1,2,4,5-Tetrafluoro-3,6-bis(2,2,2-trifluoroethoxy)benzene (CAS 6715-31-7)
- Cis-bis(benzonitrile)dichloroplatinum(II) (CAS 15617-19-3)
- 2-Chloro-6-(difluoromethyl)-3-iodo-5-methylpyridine (CAS 1804455-79-5)
- 2-(2-Amino-3-fluorophenyl)acetic acid (CAS 1822659-63-1)
- 1-[4-(4-ethylphenyl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-amine (CAS 1018143-39-9)
- 4-Nitro-6-(trifluoromethyl)-1H-indazole (CAS 1360930-13-7)
- 2',4'-Dimethoxy-[1,1'-biphenyl]-3-carbaldehyde (CAS 728919-18-4)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
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