1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N,N-dimethyl-1H-pyrrole-2-carboxamide CAS 338397-50-5
| CAS No. | 338397-50-5 |
| Molecular Formula | C13H11ClF3N3O |
| Molecular Weight | 317.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N,N-dimethyl-1H-pyrrole-2-carboxamide (CAS 338397-50-5) is a high-purity analytical reference standard with the molecular formula C13H11ClF3N3O and a molecular weight of 317.69 g/mol.
The molecular framework of 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N,N-dimethyl-1H-pyrrole-2-carboxamide (C13H11ClF3N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N,N-dimethyl-1H-pyrrole-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11ClF3N3O |
| Molecular Weight | 317.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
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Recommended Standards
- 2-Amino-8-chloro-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one (CAS 2104-68-9)
- (4Z)-4-({[(4-chlorophenyl)methyl]amino}methylidene)-1-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 320425-19-2)
- 4-(4-Chlorophenoxy)-N,N-dimethyl-6-(trifluoromethyl)pyrimidin-2-amine (CAS 338792-32-8)
- (3AR,4s,9bs)-6-chloro-9-(trifluoromethyl)-3a,4,5,9b-tetrahydro-3h-cyclopenta[c]quinoline-4-carboxylic acid (CAS 956444-95-4)
- 1-(4-Propoxy-1H-indazol-1-yl)ethan-1-one (CAS 850363-65-4)
- 4,6-Dimethylquinoline (CAS 826-77-7)
- 2-Picoline N-oxide (CAS 931-19-1)
- 3-Bromo-1-morpholin-4-ylpyrrolidin-2-one (CAS 1287217-62-2)
- 2-(1-Benzyl-1H-imidazol-4-yl)ethan-1-amine dihydrochloride (CAS 51720-40-2)
- 6,7-Dihydroxyquinoxaline-2-carboxylic acid (CAS 122234-89-3)
- 3,4-Dimethoxyphenylzinc iodide 0.5 M in Tetrahydrofuran (CAS 738580-38-6)
- 2-[3-(Trifluoromethyl)-1,2,4-oxadiazol-5-yl]ethan-1-amine (CAS 944905-86-6)
- Sivelestat sodium impurity 22 (CAS 1655497-02-1)
- D-Thr7-Tirzepatide (CAS CATO-CPTD788924)
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