3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(4-methoxyphenyl)piperidine-2,6-dione CAS 338397-68-5
| CAS No. | 338397-68-5 |
| Molecular Formula | C18H14ClF3N2O3 |
| Molecular Weight | 398.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(4-methoxyphenyl)piperidine-2,6-dione (CAS 338397-68-5), a certified reference material (molecular formula C18H14ClF3N2O3, MW 398.76 g/mol) for analytical method development and quality control.
The molecular framework of 3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(4-methoxyphenyl)piperidine-2,6-dione (C18H14ClF3N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H14ClF3N2O3 |
| Molecular Weight | 398.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-2-((3,4-dimethoxyphenyl)(1H-1,2,4-triazol-5-yl)methyl)-5-(trifluoromethyl)pyridine (CAS 338407-57-1)
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Recommended Standards
- 2-(Propylsulfanyl)-3H-indol-3-one N-(2,4,6-trichlorophenyl)hydrazone (CAS 478042-25-0)
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- 2-(Isopropylthio)-3-((2,4,6-trichlorophenyl)diazenyl)-1H-indole (CAS 478042-26-1)
- 1-(4-Chlorophenyl)-2-((5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)thio)ethan-1-one (CAS 477857-10-6)
- 2-(2-Benzothiazolylthio)ethanol (CAS 4665-63-8)
- (4-Nitrophenyl)-oxo-acetaldehydeoxime (CAS 61715-43-3)
- 2-(1-methylcyclopropyl)-1-(pyridin-4-yl)propan-2-ol (CAS 1528577-82-3)
- 1H-Isoindol-1-one, 2,3-dihydro-6,7-dimethoxy- 59084-79-6 L-1814 (CAS 59084-79-6)
- S-Adenosyl-L-Methionine Impurity 32 (CAS CATO-C4X-138132)
- 898774-04-4 1-(3,4-Dichlorophenyl)-3-(2-methoxyphenyl)propan-1-one DTXSID90644199 (CAS 898774-04-4)
- 1-Bromo-3-(chloromethyl)-2,5-difluorobenzene (CAS 1159186-57-8)
- Methyl 2-(4-(4-chlorobenzyl)phenoxy)-2-methylbutanoate (CAS 77985-11-6)
- (1-Methyl-1H-indole-2-carbonyl)glycine (CAS 204918-88-7)
- D-Ile12-Tirzepatide (CAS CATO-CPTD788921)
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