3-(4-Chlorobenzenesulfonyl)-5-(trifluoromethyl)pyridine-2-carboxamide CAS 338406-81-8
| CAS No. | 338406-81-8 |
| Molecular Formula | C13H8ClF3N2O3S |
| Molecular Weight | 364.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(4-Chlorobenzenesulfonyl)-5-(trifluoromethyl)pyridine-2-carboxamide.
3-(4-Chlorobenzenesulfonyl)-5-(trifluoromethyl)pyridine-2-carboxamide (CAS 338406-81-8), molecular formula C13H8ClF3N2O3S and molecular weight 364.73 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C13H8ClF3N2O3S, 3-(4-Chlorobenzenesulfonyl)-5-(trifluoromethyl)pyridine-2-carboxamide contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 364.73 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(4-Chlorobenzenesulfonyl)-5-(trifluoromethyl)pyridine-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8ClF3N2O3S |
| Molecular Weight | 364.73 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chlorobenzenesulfonyl Standards
- 1-(4-Chlorobenzenesulfonyl)-N-phenylpyrrolidine-2-carboxamide (CAS 317377-80-3)
- 3-(4-Chlorobenzenesulfonyl)-6-nitro-2H-chromen-2-one (CAS 866013-24-3)
- 2-(4-Chlorobenzenesulfonyl)-1-(2,4-dichlorophenyl)ethan-1-one (CAS 339108-30-4)
- 4-{6-[(4-chlorobenzenesulfonyl)methyl]-2-methylpyrimidin-4-yl}morpholine (CAS 338960-59-1)
- 1-(4-Chlorobenzenesulfonyl)-3-(2-chlorophenoxy)propan-2-ol (CAS 866131-39-7)
- 5-[(3-Chlorobenzenesulfonyl)methyl]-3-(4-chlorophenyl)-1,2-oxazole (CAS 343372-66-7)
- (2Z)-2-(4-Chlorobenzenesulfonyl)-3-{[4-(propan-2-yl)phenyl]amino}prop-2-enenitrile (CAS 1025242-00-5)
- 4-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]-4-oxobutanoic acid (CAS 560995-22-4)
Recommended Standards
- 1-(2-Chloro-6-fluorobenzyl)-3-(4-fluorobenzyl)imidazolidine-2,4,5-trione (CAS 341966-54-9)
- ethyl 4-[(2-chloro-3-pyridyl)oxy]-5,8-difluoroquinoline-3-carboxylate (CAS 245073-04-5)
- [({[(2-chloro-3-phenylprop-2-enylidene)amino]oxy}carbonyl)amino](2,6-difluorophenyl)methanone (CAS 680580-31-8)
- 2-Chloro-N-[5-(dimethylamino)-2-nitrophenyl]-5-nitrobenzamide (CAS 1079264-82-6)
- 2-(2,3-Dihydro-1h-inden-1-yl)ethan-1-amine (CAS 4458-36-0)
- (3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-methylphenyl)methanol (CAS 83141-01-9)
- Ethyl 4-Oxo-7-(4-pyridyl)-1,4-dihydroquinoline-3-carboxylate (CAS 40034-41-1)
- 2-(4-Chlorophenyl)quinoline-4-carbohydrazide (CAS 351491-60-6)
- 4-Iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (CAS 135773-25-0)
- n-(1h-Benzo[d]imidazol-2-yl)-2-(methylsulfonyl)propanamide (CAS 1280820-98-5)
- 5,6-Diamino-2-(pyridin-4-yl)pyrimidin-4(3H)-one (CAS 106823-91-0)
- 4-(4-aminophenyl)-1-methyl-1{H}-pyrazolo[3,4-{b}]pyridine-3-carboxylic acid (CAS 1354704-66-7)
- 4-Cyano-5-(difluoromethyl)-3-(trifluoromethyl)pyridine-2-acetonitrile (CAS 1806955-67-8)
- Semaglutide impurity 91 (CAS CATO-C4X-222691)
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