1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(1,3-dioxolan-2-yl)-1H-indole CAS 338410-00-7
| CAS No. | 338410-00-7 |
| Molecular Formula | C17H12ClF3N2O2 |
| Molecular Weight | 368.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(1,3-dioxolan-2-yl)-1H-indole (CAS 338410-00-7), molecular formula C17H12ClF3N2O2 and molecular weight 368.74 g/mol, is a CATO reference standard with documented purity and traceability.
1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(1,3-dioxolan-2-yl)-1H-indole (C17H12ClF3N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H12ClF3N2O2 |
| Molecular Weight | 368.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)phenyl)-4-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 1092343-50-4)
- 2-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)acetohydrazide (CAS 339099-27-3)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-methyl-4-(p-tolyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 860789-68-0)
- 3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-phenylpiperidine-2,6-dione (CAS 339030-22-7)
- 3-{1-[4-chloro-3-(trifluoromethyl)phenyl]-2,5-dimethyl-1h-pyrrol-3-yl}-2-cyanoprop-2-enoic acid (CAS 743440-55-3)
- Ethyl 2-[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]benzenecarboxylate (CAS 900015-41-0)
- Methyl 2-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)acetate (CAS 339099-19-3)
- N-(3-chloro-4-fluorophenyl)-2-((4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 263756-84-9)
Recommended Standards
- Ethyl 2-((2-chloro-4-fluorophenyl)imino)-4-(trifluoromethyl)-2,3-dihydrothiazole-5-carboxylate (CAS 937597-86-9)
- Dimethyl 5-(4-chlorophenyl)-4,6-dioxotetrahydro-2H-pyrrolo[3,4-d]isoxazole-3,3(3aH)-dicarboxylate (CAS 338420-26-1)
- 2-[(E)-2-[(2-Chloro-6-fluorophenyl)methylidene]hydrazin-1-yl]-3-(trifluoromethyl)quinoxaline (CAS 338962-29-1)
- 1-Benzyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yl trifluoromethanesulfonate (CAS 856250-49-2)
- Ethyl 3-Benzyl-3-azabicyclo[3.1.0]hexane-6-carboxylate (CAS 186376-30-7)
- 6-Fluoro-1H-indole-4-carbonitrile (CAS 1082040-44-5)
- 3-(4-chlorophenyl)-3-[(phenylsulfonyl)amino]propanoic acid (CAS 613656-63-6)
- 4-Ethynyl-2,5-difluoroaniline (CAS 1233521-10-2)
- 16,16-dimethyl Prostaglandin E1 (CAS 41692-15-3)
- 4-Amino-2-bromo-6-isopropylphenol (CAS 15028-17-8)
- 5-Hydroxypyrimidin-4(5H)-one (CAS 1822936-00-4)
- 4-Bromo-5-isopropyl-1-phenyl-1H-pyrazole-3-carboxylic acid (CAS 1456421-96-7)
- (4R,5R)-5-(Methoxycarbonyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid (CAS 67812-33-3)
- (D-Trp32)-Neuropeptide Y (porcine) trifluoroacetate salt (CAS 153549-78-1)
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