1-(2-Phenyl-1,3-thiazol-5-yl)-3-[3-(trifluoromethyl)anilino]-2-propen-1-one CAS 338414-56-5
| CAS No. | 338414-56-5 |
| Molecular Formula | C19H13F3N2OS |
| Molecular Weight | 374.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(2-Phenyl-1,3-thiazol-5-yl)-3-[3-(trifluoromethyl)anilino]-2-propen-1-one is closely related to a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(2-Phenyl-1,3-thiazol-5-yl)-3-[3-(trifluoromethyl)anilino]-2-propen-1-one (CAS 338414-56-5) is a high-purity analytical reference standard with the molecular formula C19H13F3N2OS and a molecular weight of 374.38 g/mol.
Structurally, 1-(2-Phenyl-1,3-thiazol-5-yl)-3-[3-(trifluoromethyl)anilino]-2-propen-1-one (C19H13F3N2OS) contains a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 374.38 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(2-Phenyl-1,3-thiazol-5-yl)-3-[3-(trifluoromethyl)anilino]-2-propen-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H13F3N2OS |
| Molecular Weight | 374.38 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Phenyl Standards
- 2-(2-Phenyl-1,3-thiazol-4-yl)-5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazole (CAS 400083-60-5)
- 5-(2-Phenyl-1,3-thiazol-4-yl)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazole (CAS 400079-69-8)
- 3-{[(2-methyl-1,3-thiazol-4-yl)methyl]sulfanyl}-5-[(E)-2-(phenylamino)ethenyl]-1,2-thiazole-4-carbonitrile (CAS 338778-89-5)
- N-(4-(Thiazol-2-yloxy)benzyl)-2-(trifluoromethyl)benzamide (CAS 2034616-71-0)
- (E)-[1-(1,3-Thiazol-2-yl)ethylidene]amino 3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate (CAS 866149-47-5)
- (4-(Thiazol-2-ylcarbamoyl)piperidine-1-carbonyl)-L-leucine (CAS 1814897-92-1)
- N-(4-(Thiazol-2-yloxy)benzyl)benzo[c][1,2,5]thiadiazole-5-carboxamide (CAS 2034525-71-6)
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Recommended Standards
- (S)-(3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate (CAS 2180621-71-8)
- 2-(((1H-benzo[d]imidazol-2-yl)methyl)thio)-6-cyclopropyl-4-(trifluoromethyl)nicotinonitrile (CAS 723747-95-3)
- (+)-Nortrachelogenin (CAS 61521-74-2)
- 2-(2-(2-(3,4-Dimethoxyphenyl)acetyl)-4,5-dimethoxyphenyl)acetic acid (CAS 26954-85-8)
- Dibenzylphosphinic acid (CAS 7369-51-9)
- 3-(4-Methyl-1,3-thiazol-5-yl)propan-1-amine (CAS 325491-86-9)
- N-(2-Cyclopropylethyl)-6-(4-{6-[(2-cyclopropylethyl)carbamoyl]pyridazin-3-yl}piperazin-1-yl)pyridazine-3-carboxamide (CAS 840488-88-2)
- N-[5-(1-Adamantyl)-1,3,4-thiadiazol-2-yl]-2-chloro-N-phenylacetamide (CAS 1706460-53-8)
- Benzo[b]thiophene-6-carbonitrile 1,1-dioxide (CAS 1186519-55-0)
- (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl (9Z,12Z)-octadeca-9,12-dienoate (CAS 127592-95-4)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-2-cyclopropylacetic acid (CAS 2642726-08-5)
- 4-Amino-6-(tert-butyl)-1,3,5-triazin-2-ol (CAS 175204-68-9)
- 2-(Acetamidomethyl)pyridine 1-oxide (CAS 53175-17-0)
- Liraglutide Impurity 14 TFA Salt (CAS CATO-C4X-199214)
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