1-Cyclopropanecarbonyl-9b-phenyl-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one CAS 338414-92-9
| CAS No. | 338414-92-9 |
| Molecular Formula | C20H18N2O2 |
| Molecular Weight | 318.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-Cyclopropanecarbonyl-9b-phenyl-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one (CAS 338414-92-9), molecular formula C20H18N2O2 and molecular weight 318.37 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-Cyclopropanecarbonyl-9b-phenyl-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one (C20H18N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H18N2O2 |
| Molecular Weight | 318.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 1'-Boc-1,2-dihydro-2-oxo-spiro[4H-3,1-benzoxazine-4,4'-piperidine] (CAS 84060-08-2)
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- 1-Benzyl-N-methyl-2-oxo-N-phenyl-1,2-dihydropyridine-3-carboxamide (CAS 338755-17-2)
- 2-((3-Propionamidophenyl)carbamoyl)cyclohexane-1-carboxylic acid (CAS 925194-02-1)
- tert-Butyl 2,6-dichloronicotinate (CAS 1013647-75-0)
- 3,5-Dimethylthioanisole (CAS 66794-11-4)
- 2-((Benzyloxy)methyl)-4-hydroxy-5-nitropyridazin-3(2H)-one (CAS 92574-76-0)
- (3,5-Dimethylphenyl)methyl 4-(1H-indol-3-yl)butanoate (CAS 860784-03-8)
- Tetracaine Impurity 7 (CAS 10012-47-2)
- 1-(Trifluoroethoxy)-2-methyl-4-nitrobenzene (CAS 96308-26-8)
- (3-(Cyclopropylmethoxy)phenyl)methanamine (CAS 848444-80-4)
- 2-(6-Methoxynaphthalen-2-yl)-1-morpholinoethanethione (CAS 53077-21-7)
- 6-Chloro-3-propan-2-yl-[1,2,4]triazolo[4,3-b]pyridazine (CAS 72392-97-3)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
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