(2E)-2-{[(2-chlorophenyl)amino]methylidene}-3,4-dihydro-2H-1,4-benzothiazin-3-one CAS 338416-69-6
| CAS No. | 338416-69-6 |
| Molecular Formula | C15H11ClN2OS |
| Molecular Weight | 302.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (2E)-2-{[(2-chlorophenyl)amino]methylidene}-3,4-dihydro-2H-1,4-benzothiazin-3-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(2E)-2-{[(2-chlorophenyl)amino]methylidene}-3,4-dihydro-2H-1,4-benzothiazin-3-one (CAS 338416-69-6), molecular formula C15H11ClN2OS and molecular weight 302.78 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (2E)-2-{[(2-chlorophenyl)amino]methylidene}-3,4-dihydro-2H-1,4-benzothiazin-3-one (C15H11ClN2OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (2E)-2-{[(2-chlorophenyl)amino]methylidene}-3,4-dihydro-2H-1,4-benzothiazin-3-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11ClN2OS |
| Molecular Weight | 302.78 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related E Standards
- (2E)-2-{[(3-chlorophenyl)amino]methylidene}-3,4-dihydro-2H-1,4-benzothiazin-3-one (CAS 1164490-94-1)
- N-(2-Chlorophenyl)-3-(methylsulfonyl)pyrrolidine-1-carboxamide (CAS 1448129-87-0)
- 4-(2-Chlorophenyl)-2-(2-hydrazinylpyridin-4-yl)thiazole (CAS 1779120-75-0)
- 4-[2-(4-Chlorophenyl)-1,3-thiazol-5-yl]-N-methylpyrimidin-2-amine (CAS 1823183-26-1)
- (3E)-4-[6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]but-3-en-2-one (CAS 338793-19-4)
- 2-(((4-Chlorophenyl)thio)methyl)quinazolin-4-ol (CAS 443918-05-6)
- 2-(4-Chlorophenyl)-5-[2-(methylsulfanyl)phenyl]-1,3,4-oxadiazole (CAS 339014-28-7)
- 2-{[(4-chlorophenyl)methyl]sulfanyl}-5-phenyl-1,3,4-oxadiazole (CAS 28923-55-9)
Recommended Standards
- (2E)-7-Chloro-2-[(phenylamino)methylidene]-3,4-dihydro-2H-1,4-benzothiazin-3-one (CAS 338417-01-9)
- 1-[4-(benzenesulfonyl)piperazin-1-yl]-2-chloroethan-1-one (CAS 722491-33-0)
- Manganese(II) tungsten oxide, 99.9% (metals basis) (CAS 14177-46-9)
- 2-Chloro-N-(3-cyano-4,5-dihydronaphtho[1,2-b]thiophen-2-yl)acetamide (CAS 1365962-07-7)
- 2-(Difluoromethyl)-3-fluoro-4-methoxyphenol (CAS 2090540-48-8)
- 2-((2,6-Dichlorobenzyl)oxy)-3-methylbenzaldehyde (CAS 1427024-36-9)
- 4-(3-Hydroxypropoxy)-2,3-dimethylpyridine 1-oxide (CAS 209914-28-3)
- 3-amino-1,5,6-trimethyl-1H,4H,5H-pyrazolo[4,3-c]pyridin-4-one (CAS 1018274-29-7)
- 3-(Difluoromethoxy)-1,2,4,5-tetrafluoro-benzene (CAS 155466-60-7)
- 4-(Naphthalen-1-yl)pyridine (CAS 78903-68-1)
- 6-methyl-2,1-benzoxazole-3-carboxylic acid (CAS 1204297-40-4)
- 6-(2,6-Dichlorobenzyl)-2-(3,4-dichlorophenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine (CAS 477858-94-9)
- 1-[4'-(Methylsulfanyl)[1,1'-biphenyl]-2-yl] ethanone (CAS 893739-21-4)
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