1-(3-Chlorobenzyl)-N-(2,4-difluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide CAS 338754-88-4
| CAS No. | 338754-88-4 |
| Molecular Formula | C19H13ClF2N2O2 |
| Molecular Weight | 374.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(3-Chlorobenzyl)-N-(2,4-difluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 338754-88-4) is a high-purity analytical reference standard with the molecular formula C19H13ClF2N2O2 and a molecular weight of 374.77 g/mol.
The molecular framework of 1-(3-Chlorobenzyl)-N-(2,4-difluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (C19H13ClF2N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H13ClF2N2O2 |
| Molecular Weight | 374.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorobenzyl Standards
- 1-(3-Chlorobenzyl)-N-(2,4-difluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS 478065-96-2)
- 1-(4-Chlorobenzyl)-N-(2,4-difluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS 338782-79-9)
- 3-(4-Chlorobenzyl)-5,5-dimethyl-1-(5-nitropyridin-2-yl)imidazolidine-2,4-dione (CAS 900019-17-2)
- 3-(4-Chlorobenzyl)-4-oxo-2-(phenylimino)-1,3-thiazinane-6-carboxylic acid (CAS 312512-86-0)
- 2-((4-Chlorobenzyl)thio)-3-(thiophen-2-yl)-1,4-diazaspiro[4.5]deca-1,3-diene (CAS 1276469-63-6)
- 1-((2-Chlorobenzyl)sulfonyl)-3-(2-chlorophenoxy)propan-2-ol (CAS 478260-53-6)
- 3-((4-Chlorobenzyl)thio)-N-(p-tolyl)thiophene-2-carboxamide (CAS 251097-06-0)
- 6-((2-Chlorobenzyl)thio)-9-cyclohexyl-9H-purin-2-amine (CAS 93946-94-2)
Recommended Standards
- 1-(2-Chloro-6-fluorobenzyl)-N-(2-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 946302-89-2)
- 3-Amino-1-(benzo[d][1,3]dioxol-5-yl)-5,6,7,7a-tetrahydro-1H-indol-2(4H)-one (CAS 53446-25-6)
- N-(1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-pyrrol-2-yl)morpholine-4-carboxamide (CAS 338407-68-4)
- 1-Benzyl-5-chloro-N-(2,4-difluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS 339024-42-9)
- Methyl-3-(1h-1,2,4-triazole-1-yl)-butyrate (CAS 672285-89-1)
- 2-(4-(tert-Butoxycarbonyl)phenyl)-2-hydroxyacetic acid (CAS 1263282-79-6)
- 4-Oxo-4-(2,3,5,6-tetramethylphenyl)butanoic acid (CAS 134948-69-9)
- N-(azetidin-3-yl)propionamide (CAS 1365212-31-2)
- 6-Chloro-4-methoxy Nicotinic Acid (CAS 716362-10-6)
- (R)-6-bromo-8-fluorochroman-4-amine (CAS 1212825-38-1)
- 3-Bromo-5-methylisonicotinonitrile (CAS 51454-50-3)
- 4-Amino-N-ethyl-2-(piperazin-1-yl)pyrimidine-5-carboxamide (CAS 105161-82-8)
- 3-Chloromethyl-5-methylpyridine (CAS 158876-83-6)
- Neuropeptide Y (22-36) (CAS 119019-65-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com