5-(Trifluoromethyl)-3-[3-(trifluoromethyl)phenoxy]pyridine-2-carboxamide CAS 338758-33-1
| CAS No. | 338758-33-1 |
| Molecular Formula | C14H8F6N2O2 |
| Molecular Weight | 350.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(Trifluoromethyl)-3-[3-(trifluoromethyl)phenoxy]pyridine-2-carboxamide.
5-(Trifluoromethyl)-3-[3-(trifluoromethyl)phenoxy]pyridine-2-carboxamide (CAS 338758-33-1) is a high-purity analytical reference standard with the molecular formula C14H8F6N2O2 and a molecular weight of 350.22 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 5-(Trifluoromethyl)-3-[3-(trifluoromethyl)phenoxy]pyridine-2-carboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 350.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8F6N2O2 |
| Molecular Weight | 350.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Trifluoromethyl Standards
- (6-(Trifluoromethyl)pyridin-3-yl)methyl 6-(trifluoromethyl)nicotinate (CAS 1781241-48-2)
- 5-(Trifluoromethyl)-3-[4-(trifluoromethyl)phenoxy]pyridine-2-carboxamide (CAS 338759-47-0)
- 3-(5-(3,5-Bis(trifluoromethyl)phenyl)furan-2-yl)acrylic acid (CAS 406725-93-7)
- 4-[3,5-Bis(trifluoromethyl)phenoxy]benzoic Acid (CAS 762286-35-1)
- 3-(2-Oxo-3-(4-(trifluoromethyl)phenyl)imidazolidin-1-yl)benzoic acid (CAS 651748-86-6)
- 1-Methyl-4-((3-(trifluoromethyl)benzyl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (CAS 685109-25-5)
- Methyl 9-(((trifluoromethyl)sulfonyl)oxy)-6,7-dihydro-5H-benzo[7]annulene-3-carboxylate (CAS 2114341-38-5)
- 2-[1-Methyl-3-(trifluoromethyl)-1H-thieno[2,3-c]pyrazol-5-yl]-5-phenyl-1,3,4-oxadiazole (CAS 400082-47-5)
Recommended Standards
- 4-[2,4-dichloro-5-(2-methoxyethoxy)phenyl]-3,5-thiomorpholinedione (CAS 339015-07-5)
- 4-(4-(3,4-Dichlorophenyl)thiazol-2-yl)benzoic acid (CAS 338407-84-4)
- 5-Methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrazolo[1,5-a]pyrimidin-7-amine (CAS 942589-62-0)
- 4-(4-(2,4-Dichlorophenyl)thiazol-2-yl)benzoic acid (CAS 320420-89-1)
- 1-Benzyloctahydro-1H-pyrrolo[3,4-b]pyridine (CAS 933688-09-6)
- Thieno[3,2-b]pyridin-7-ol (CAS 107818-20-2)
- 2,2"-Dimethyl-[1,1':4',1"-terphenyl]-4,4"-diamine (CAS 1154654-11-1)
- 3-[(2-Hydroxyphenyl)amino]-5,5-dimethylcyclohex-2-en-1-one (CAS 51924-59-5)
- Solifenacin Impurity 29 (CAS CATO-C4X-105329)
- 5β-PREGNAN-3α, 6α-DIOL-20-ONE (CAS 570-78-5)
- 4-(2,3-Dimethylphenoxy)-6-phenylfuro[2,3-d]pyrimidine (CAS 866039-03-4)
- 2-Amino-3-(2-chloro-6-fluorophenyl)propanoic acid (CAS 603940-86-9)
- 1-(4-Fluorophenyl)-2-methoxyethan-1-amine (CAS 321839-91-2)
- Des-Ala35-Tirzepatide (CAS CATO-CPTD788939)
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