3-Chloro-2-[(E)-2-(pyridin-3-yl)ethenyl]-5-(trifluoromethyl)pyridine CAS 338762-10-0
| CAS No. | 338762-10-0 |
| Molecular Formula | C13H8ClF3N2 |
| Molecular Weight | 284.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-2-[(E)-2-(pyridin-3-yl)ethenyl]-5-(trifluoromethyl)pyridine (CAS 338762-10-0), molecular formula C13H8ClF3N2 and molecular weight 284.66 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-2-[(E)-2-(pyridin-3-yl)ethenyl]-5-(trifluoromethyl)pyridine (C13H8ClF3N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H8ClF3N2 |
| Molecular Weight | 284.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 6-Chloro-N-(2,2-dimethoxyethyl)-4-(trifluoromethyl)pyridin-2-amine (CAS 1208081-17-7)
- 4'-Chloro-2'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde (CAS 1242339-91-8)
- 5-Chloro-2-morpholino-6-nitrooxazolo[4,5-b]pyridine (CAS 1801345-37-8)
- (2-Chloro-5-(trifluoromethyl)phenyl)(phenyl)methanone (CAS 789-96-8)
- 3-Chloro-N-(2,2-dimethoxyethyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 338406-44-3)
- 4'-Chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde (CAS 893637-94-0)
- 7-Chloro-5-morpholino-4-nitrobenzo[c][1,2,5]oxadiazole (CAS 312590-63-9)
- Methyl 1-((3-chloro-4-fluorophenoxy)methyl)-1h-pyrazole-3-carboxylate (CAS 1001500-21-5)
Recommended Standards
- 3-(4-Fluoro-3-(trifluoromethyl)phenyl)benzaldehyde (CAS 544474-55-7)
- (4-chlorophenyl)[4-(trifluoromethyl)phenyl]methanone (CAS 34328-31-9)
- (4-Chlorophenyl)(3-(trifluoromethyl)phenyl)methanone (CAS 91503-65-0)
- 1-((3-Chloro-4-fluorophenoxy)methyl)-1h-pyrazole-3-carbohydrazide (CAS 1004193-94-5)
- Pcb No. 116 (CAS 18259-05-7)
- N2,N7-Diphenyl-N2,N7-di-m-tolyl-9,9'-spirobi[fluorene]-2,7-diamine (CAS 1033035-83-4)
- tert-Butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate (CAS 1359704-84-9)
- 4-(8-(Trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)benzoic acid (CAS 2197062-06-7)
- (4-(Difluoromethoxy)Benzyl)Hydrazine Dihydrochloride (CAS 887596-65-8)
- 3-Bromo-2-chloro-6-(trifluoromethyl)aniline (CAS 1804384-58-4)
- 4-Hydroxy-4-phenylbutan-2-one (CAS 5381-93-1)
- 4-[(4-{[(2Z)-3-phenylprop-2-enoyl]oxy}phenyl)sulfanyl]phenyl (2Z)-3-phenylprop-2-enoate (CAS 328263-25-8)
- Eltrombopag Impurity 33 (CAS 16419-60-6)
- D-[γ-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226254)
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