2-[(3E)-3-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}-1-(dimethylamino)propylidene]propanedinitrile CAS 338773-49-2
| CAS No. | 338773-49-2 |
| Molecular Formula | C14H12ClF3N6 |
| Molecular Weight | 356.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-[(3E)-3-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}-1-(dimethylamino)propylidene]propanedinitrile (C14H12ClF3N6) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-[(3E)-3-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}-1-(dimethylamino)propylidene]propanedinitrile (CAS 338773-49-2) is a high-purity analytical reference standard with the molecular formula C14H12ClF3N6 and a molecular weight of 356.73 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H12ClF3N6 |
| Molecular Weight | 356.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related E Standards
- Benzyl 2-chloro-2-(2-(3-(trifluoromethyl)phenyl)hydrazono)acetate (CAS 1000576-10-2)
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- N-(3-Chloro-4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)cyclopropanecarboxamide (CAS 338962-08-6)
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Recommended Standards
- 3-(2-Chloroacetamido)-N-(3-(trifluoromethyl)phenyl)benzamide (CAS 565171-06-4)
- (S)-BAY 73-6691 (CAS 794568-91-5)
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- Ethoxydimethyl(octadecyl)silane (CAS 97330-35-3)
- tert-Butyl 6-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate (CAS 374795-29-6)
- 1-(2-Acetyl-4,5-dimethoxyphenyl)-3-phenylurea (CAS 218134-95-3)
- 5-bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1111638-01-7)
- 2-Amino-N-methyl-N-(thiazol-5-ylmethyl)acetamide (CAS 1353983-85-3)
- Methyl 5-(Ethylsulfonyl)-2-methoxybenzoate (CAS 62140-67-4)
- 3-Formyl-1H-pyrrolo[2,3-c]pyridine-4-carbonitrile (CAS 1190320-19-4)
- Methyl 4-bromo-5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate (CAS 2748790-07-8)
- (1R)-1-(Iodomethyl)-3,3-dimethyl-7-oxabicyclo[2.2.1]heptan-2-one (CAS 102304-99-4)
- 2H,4H,6H-Furo[3,4-c]pyrazol-6-one (CAS 504417-55-4)
- Semaglutide Impurity 192 (CAS CATO-C4X-2226192)
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