5,6-Dichloro-2-(2-chloropyridin-3-yl)-1-(4-methoxybenzyl)-1H-benzo[d]imidazole CAS 338774-36-0

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5,6-Dichloro-2-(2-chloropyridin-3-yl)-1-(4-methoxybenzyl)-1H-benzo[d]imidazole.

5,6-Dichloro-2-(2-chloropyridin-3-yl)-1-(4-methoxybenzyl)-1H-benzo[d]imidazole (CAS 338774-36-0) is a high-purity analytical reference standard with the molecular formula C20H14Cl3N3O and a molecular weight of 418.70 g/mol.

5,6-Dichloro-2-(2-chloropyridin-3-yl)-1-(4-methoxybenzyl)-1H-benzo[d]imidazole (C20H14Cl3N3O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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