2,2-Difluoro-1-(4-methylpiperazin-1-yl)-2-phenoxyethan-1-one CAS 338791-97-2
| CAS No. | 338791-97-2 |
| Molecular Formula | C13H16F2N2O2 |
| Molecular Weight | 270.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2,2-Difluoro-1-(4-methylpiperazin-1-yl)-2-phenoxyethan-1-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2,2-Difluoro-1-(4-methylpiperazin-1-yl)-2-phenoxyethan-1-one (CAS 338791-97-2) is a high-purity analytical reference standard with the molecular formula C13H16F2N2O2 and a molecular weight of 270.28 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 2,2-Difluoro-1-(4-methylpiperazin-1-yl)-2-phenoxyethan-1-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 270.28 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2,2-Difluoro-1-(4-methylpiperazin-1-yl)-2-phenoxyethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H16F2N2O2 |
| Molecular Weight | 270.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoro Standards
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- (E)-5,5'-difluoro-2,3'-biindolinylidene (CAS CATO-C4X-133376)
- 4,4-Difluoro-1-(4-methoxyphenyl)cyclohexane-1-carboxylic acid (CAS 1897698-13-3)
- 4,6-Difluoro-N-((tetrahydrofuran-2-yl)methyl)benzo[d]thiazol-2-amine (CAS 1219914-77-8)
- 4,6-Difluoro-2-(piperidin-4-yloxy)-1,3-benzothiazole (CAS 1283108-95-1)
- (R)-2,2-Difluoro-6-sulfamoyl-6-azaspiro[2.5]octane-1-carboxylic acid (CAS 2384170-65-2)
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Recommended Standards
- 2,2’-Dimethoxybenzil (CAS 6706-92-9)
- 2,3-Diphenylsuccinic acid (CAS 7584-72-7)
- 2,2'-(Ethane-1,2-diylbis(oxy))dibenzaldehyde (CAS 52118-10-2)
- 2-Acetoxy-2-methoxybenzophenone (CAS 890098-81-4)
- 1,2,4-Trichloro-5-fluorobenzene (CAS 400-04-4)
- 2-Chloro-4-(cyclopentyloxy)-5-iodo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1618663-33-4)
- Methyl 2-(4,6-Dimethoxypyrimidin-2-yl)cyclohexanoate (CAS 870083-40-2)
- 3-(4-Fluorophenyl)-5,6-dihydro-4H-pyrrolo[3,2-d]isoxazole (CAS 603067-22-7)
- N-(thiophen-3-ylmethyl)prop-2-en-1-amine hydrochloride (CAS 1049713-41-8)
- 1-(3-Fluoro-5-isobutoxyphenyl)ethan-1-one (CAS 1443302-81-5)
- 2-(1-Methyl-1H-indol-3-yl)acetonitrile (CAS 51584-17-9)
- 4-cyano-3-fluorobenzoic acid (CAS 176508-81-9)
- 2-(2-Amino-6-(piperidin-4-yl)pyrimidin-4-yl)ethan-1-ol hydrochloride (CAS 1361112-65-3)
- Palmitoyl Tripeptide -5 · 2 TFA (CAS 623172-56-5)
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