N-(2,6-Diethylphenyl)-2,2-difluoro-2-[3-(trifluoromethyl)phenoxy]acetamide CAS 338792-18-0
| CAS No. | 338792-18-0 |
| Molecular Formula | C19H18F5NO2 |
| Molecular Weight | 387.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures N-(2,6-Diethylphenyl)-2,2-difluoro-2-[3-(trifluoromethyl)phenoxy]acetamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
N-(2,6-Diethylphenyl)-2,2-difluoro-2-[3-(trifluoromethyl)phenoxy]acetamide (CAS 338792-18-0), molecular formula C19H18F5NO2 and molecular weight 387.34 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(2,6-Diethylphenyl)-2,2-difluoro-2-[3-(trifluoromethyl)phenoxy]acetamide (C19H18F5NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C19H18F5NO2 |
| Molecular Weight | 387.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related N Standards
- N-(1-(2-((2,6-Diethylphenyl)amino)-2-oxoethyl)-piperidin-4-yl)-3-fluorobenzamide (CAS 836679-42-6)
- N-(2,6-Diethylphenyl)-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (CAS 339027-88-2)
- N-(2,6-diethylphenyl)-3,4,5-trimethoxybenzamide (CAS 352705-45-4)
- N-(2,6-diethylphenyl)-2-((4,6-dimethylpyrimidin-2-yl)thio)acetamide (CAS 332922-26-6)
- N-(2,6-Diethylphenyl)-2-(2-ethoxyphenoxy)acetamide (CAS 449155-02-6)
- (R)-3-(2,6-diethylphenyl)-1-(2-hydroxy-1-phenylethyl)-4,5-dihydro-1H-imidazol-3-ium (CAS 1630817-20-7)
- 2-(2,6-Diethylphenyl)-1,3-dioxoisoindoline-5-carboxylic acid (CAS 100844-07-3)
- N-(2,6-diethylphenyl)-6-(1H-1,2,4-triazol-1-yl)nicotinamide (CAS 672951-16-5)
Recommended Standards
- 3-O-Methyl-L-DOPA 4-Glucuronide (CAS 52583-26-3)
- Pomalidomide-amido-C3-COOH (CAS 2162120-77-4)
- (1S,2R,3S,4R)-1-cyanopentane-1,2,3,4,5-pentayl pentaacetate (CAS 35439-42-0)
- Pomalidomide-CO-C2-methyl ester (CAS 444287-81-4)
- tert-Butyl (2S)-2-[(1R)-1-hydroxyethyl]pyrrolidine-1-carboxylate (CAS 310450-41-0)
- 2-Chloro-4-methoxy-3-(trifluoromethyl)pyridine (CAS 1163693-02-4)
- N-Allyl-2-aminobenzamide (CAS 4943-82-2)
- 4-Phenyl-3-(1H-pyrrol-1-yl)thiophene-2-carbohydrazide (CAS 1779132-51-2)
- 1-(2-Fluorophenyl)guanidine hydrochloride (CAS 1187927-51-0)
- 2-Fluoro-8-azaspiro[4.5]Decane (CAS 1823315-37-2)
- [(3aR,6S,6aR)-6-(Benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5,5-diyl]dimethanol (CAS 63593-03-3)
- tert-Butyl (S)-(1-cyclopropyl-3-oxopropan-2-yl)carbamate (CAS 881902-36-9)
- (2-Amino-5-chlorophenyl)(pyridin-2-yl)methanone (CAS 1830-42-8)
- Semaglutide Impurity 18 (CAS 1671100-14-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com