6-(3-(Trifluoromethyl)phenoxy)nicotinaldehyde CAS 338967-16-1
| CAS No. | 338967-16-1 |
| Molecular Formula | C13H8F3NO2 |
| Molecular Weight | 267.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-(3-(Trifluoromethyl)phenoxy)nicotinaldehyde (CAS 338967-16-1), molecular formula C13H8F3NO2 and molecular weight 267.20 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 6-(3-(Trifluoromethyl)phenoxy)nicotinaldehyde (C13H8F3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 267.20 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-(3-(Trifluoromethyl)phenoxy)nicotinaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8F3NO2 |
| Molecular Weight | 267.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 4-((5-(Trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde (CAS 103962-21-6)
- 4-((3-(Trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde (CAS 1086379-05-6)
- 4-((6-(Trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde (CAS 1086379-09-0)
- 5-Phenyl-3-(trifluoromethyl)-2-pyridinecarboxylic acid (CAS 1211578-17-4)
- 3-Phenyl-6-(trifluoromethyl)-2-pyridinecarboxylic acid (CAS 1214381-18-6)
- 3-Phenyl-5-(trifluoromethyl)picolinic acid (CAS 1214390-26-7)
- 2-(4-(Trifluoromethyl)phenyl)isonicotinic acid (CAS 1225900-99-1)
- 2-(2-(Trifluoromethyl)phenyl)nicotinic acid (CAS 1225923-56-7)
Recommended Standards
- 6-(3-(Trifluoromethoxy)phenyl)nicotinaldehyde (CAS 898796-59-3)
- 6-(3-(Trifluoromethyl)phenyl)nicotinic acid (CAS 887976-13-8)
- 6-(2-(Trifluoromethyl)phenyl)picolinic acid (CAS 887983-43-9)
- 6-(3-(Trifluoromethyl)phenyl)picolinic acid (CAS 887982-06-1)
- Benzo[d][1,3]dioxol-5-yl(pyridin-2-yl)methanone (CAS 27693-43-2)
- Bis(4-(2,2,2-trifluoroethoxy)cyclohexan-1-amine) trihydrochloride (CAS 1181458-73-0)
- 3-Ethyl-2-mercapto-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (CAS 59898-66-7)
- 6-Amino-4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-3-propyl-2H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile (CAS 1020251-73-3)
- (3AS,4R,5S,6aR)-5-(Benzyloxy)-4-((benzyloxy)methyl)-hexahydro-2H-cyclopenta[b]furan-2-one (CAS 114826-79-8)
- 4-((1-Ethyl-1h-1,2,4-triazol-5-yl)methyl)thiazol-2-amine (CAS 1249176-14-4)
- (1-Methyl-1H-pyrrol-2-ylmethyl)-pyridin-3-ylmethyl-amine hydrochloride (CAS 1052415-16-3)
- 4-(Benzyloxy)-6-methoxypyridine-2-sulfonyl chloride (CAS 1393572-89-8)
- 4-Methyl-5-nitro-2-(4-(trifluoromethyl)phenoxy)pyridine (CAS 1956366-33-8)
- Insulin Degludec Impurity 2 (CAS CATO-C4X-21572)
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