(3Z)-3-({[4-(trifluoromethyl)phenyl]amino}methylidene)-1,3-dihydro-2-benzofuran-1-one CAS 338976-17-3
| CAS No. | 338976-17-3 |
| Molecular Formula | C16H10F3NO2 |
| Molecular Weight | 305.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (3Z)-3-({[4-(trifluoromethyl)phenyl]amino}methylidene)-1,3-dihydro-2-benzofuran-1-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(3Z)-3-({[4-(trifluoromethyl)phenyl]amino}methylidene)-1,3-dihydro-2-benzofuran-1-one (CAS 338976-17-3) is a high-purity analytical reference standard with the molecular formula C16H10F3NO2 and a molecular weight of 305.25 g/mol.
(3Z)-3-({[4-(trifluoromethyl)phenyl]amino}methylidene)-1,3-dihydro-2-benzofuran-1-one (C16H10F3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H10F3NO2 |
| Molecular Weight | 305.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Z Standards
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- 4-[(E)-[4-(trifluoromethyl)phenyl]methyleneamino]-3h-isobenzofuran-1-one (CAS 1207454-88-3)
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Recommended Standards
- (3Z)-3-({[3-(trifluoromethyl)phenyl]amino}methylidene)-1,3-dihydro-2-benzofuran-1-one (CAS 303995-50-8)
- (4S)-4-(4-Trifluoromethyl-benzyl)-L-glutamic acid (CAS 207508-60-9)
- (2r,5r)-2-Benzamido-6,6,6-trifluoro-5-hydroxyhexanoic acid (CAS 1955474-08-4)
- (Z)-3-(4-(trifluoromethoxy)benzylidene)indolin-2-one (CAS 860784-42-5)
- 5-[5-Amino-3-(4-fluorophenyl)-2-pyrazinyl]-1-isopropylpyridin-2(1H)-one (CAS 851087-60-0)
- 6-Chloropyridine-3,4-diol (CAS 1196156-68-9)
- 2-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid (CAS 80537-08-2)
- (3-(Benzylthio)phenyl)boronic acid (CAS 854778-48-6)
- 5-(p-Tolyl)pyrrolidin-2-one (CAS 128100-30-1)
- 2-Fluoro-4-(perfluoroethyl)benzoic acid (CAS 1263285-60-4)
- (5-(Difluoromethyl)-2-fluoro-3-(trifluoromethyl)pyridin-4-yl)methanamine (CAS 1806989-78-5)
- 4-(2,4-Dimethoxyphenyl)-6-(3,4-dimethylphenyl)pyrimidin-2-amine (CAS 1354939-71-1)
- 2-((4-Chlorophenyl)thio)-N-(2,3-dichlorophenyl)acetamide (CAS 285980-82-7)
- Macrophage Inhibitory Peptide (CAS 41961-56-2)
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