(E)-{[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]oxy}(1-phenylethylidene)amine CAS 338978-34-0
| CAS No. | 338978-34-0 |
| Molecular Formula | C18H11F6N3O |
| Molecular Weight | 399.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(E)-{[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]oxy}(1-phenylethylidene)amine (CAS 338978-34-0) is a high-purity analytical reference standard with the molecular formula C18H11F6N3O and a molecular weight of 399.29 g/mol.
(E)-{[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]oxy}(1-phenylethylidene)amine (C18H11F6N3O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H11F6N3O |
| Molecular Weight | 399.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- (E)-[(2,6-Dichlorophenyl)methoxy]({[3-nitro-4-(propan-2-ylsulfanyl)phenyl]methylidene})amine (CAS 303996-36-3)
- 1-(2-((5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl)amino)phenyl)ethan-1-one (CAS 337928-11-7)
- (4Z)-1-Phenyl-3-(trifluoromethyl)-4-({[4-(trifluoromethyl)phenyl]amino}methylidene)-4,5-dihydro-1H-pyrazol-5-one (CAS 477851-33-5)
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