6-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine CAS 338979-12-7
| CAS No. | 338979-12-7 |
| Molecular Formula | C13H11ClF3N5 |
| Molecular Weight | 329.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 6-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
6-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (CAS 338979-12-7) is a high-purity analytical reference standard with the molecular formula C13H11ClF3N5 and a molecular weight of 329.71 g/mol.
6-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (C13H11ClF3N5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11ClF3N5 |
| Molecular Weight | 329.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related chloro Standards
- 4-{3-chloro-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl}-1-methyl-5-(trifluoromethyl)-1H-pyrazole (CAS 956370-70-0)
- 2-[2-Chloro-5-(trifluoromethyl)pyridin-4-ylamino]-N-methylbenzamide (CAS 1061358-71-1)
- Ethyl 2-chloro-6-(4-trifluorophenyl)nicotinate (CAS 1261802-95-2)
- 4-(6-Chloro-4-trifluoromethyl-pyridin-2-yl)-benzoic acid ethyl ester (CAS 1311278-42-8)
- N'-(6-chloro-4-(trifluoromethyl)pyridin-2-yl)-N'-methylbenzohydrazide (CAS 1431555-17-7)
- N-[6-Chloro-4-(trifluoromethyl)pyridin-2-yl]-2-methylbenzohydrazide (CAS 1795304-95-8)
- 2-(4-Chloro-2-methylphenoxy)-2,2-difluoro-N-(4-fluorophenyl)acetamide (CAS 339011-04-0)
- 2-[3-Chloro-5-(trifluoromethyl)-2-pyridyl]-3-phenylpropanoic acid (CAS 1987008-07-0)
Recommended Standards
- Bis(triisopropylsilyl)amine (CAS 923027-92-3)
- (E)-N'-{5-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]pyrimidin-2-yl}-N,N-dimethylmethanimidamide (CAS 339010-68-3)
- 1-tert-Butyl 2-chloromethyl (2S,4R)-4-(difluoromethoxy)pyrrolidine-1,2-dicarboxylate (CAS 2137062-11-2)
- 4-(Benzylideneamino)-7-chloro-6-fluorocinnoline-3-carboxylic acid (CAS 159831-77-3)
- (R)-2-methylbutane-2-sulfinamide (CAS 446021-71-2)
- 5-(4-Dimethylamino-benzylidene)-2-thioxo-imidazolidin-4-one (CAS 41250-31-1)
- 4-Hepten-3-one,1,7-bis(3,4-dihydroxyphenyl)- ,(4E)- 41137-87-5 (CAS 41137-87-5)
- 6-Hydroxy-2-(methylthio)-5-phenylpyrimidin-4(3H)-one (CAS 6327-17-9)
- Elagolix Impurity 31 (CAS 830346-48-0)
- Beta-D-Glucosamine (CAS 14257-69-3)
- 2-(4-Isopropylphenyl)quinoline-4-carboxylic acid (CAS 50733-96-5)
- Ethyl 1-Cbz-3-fluoropiperidine-3-carboxylate (CAS 1111640-60-8)
- (2R,4S)-4-Benzyl-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (CAS 1229439-64-8)
- Semaglutide impurity 44 (CAS CATO-C4X-222644)
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