4,4'-Difluorobenzophenone-2-carboxylic acid CAS 338982-44-8
| CAS No. | 338982-44-8 |
| Molecular Formula | C14H8F2O3 |
| Molecular Weight | 262.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4,4'-Difluorobenzophenone-2-carboxylic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4,4'-Difluorobenzophenone-2-carboxylic acid (CAS 338982-44-8) is a high-purity analytical reference standard with the molecular formula C14H8F2O3 and a molecular weight of 262.21 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, 4,4'-Difluorobenzophenone-2-carboxylic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 262.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8F2O3 |
| Molecular Weight | 262.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Difluorobenzophenone Standards
Recommended Standards
- 4,4'-(Ethane-1,2-diylbis(oxy))bis(4-oxobutanoic acid) (CAS 35415-14-6)
- 4-Acetamido-3-nitrobenzene-1-sulfonyl fluoride (CAS 365-65-1)
- 2-benzoyl-4,5-difluorobenzoic acid (CAS 937635-08-0)
- 4-Fluorobenzoic anhydride (CAS 25569-77-1)
- (1R,3r)-1-amino-3-methylcyclobutane-1-carboxylic acid hydrochloride (CAS 2137050-05-4)
- 2,2-Dimethyl-3-oxobutanenitrile (CAS 37719-02-1)
- 5-Aminoimidazo[2,1-b]thiazol-6-ol (CAS 863203-50-3)
- Ethyl 6-bromo-2-(trifluoromethyl)-2H-chromene-3-carboxylate (CAS 1160474-50-9)
- 4-(Tert-pentyloxy)pyridin-3-amine (CAS 1039334-74-1)
- 3-Mercapto-N,N-dimethylbenzamide (CAS 801315-71-9)
- Methyl (2E)-4-methoxybut-2-enoate (CAS 59424-95-2)
- 4-Ethoxycarbonyl-3-methoxyphenylboronic acid (CAS 911312-76-0)
- (S)-2-(2-Bromophenyl)-4-methyl-4,5-dihydrooxazole (CAS 154701-59-4)
- Semaglutide impurity 24 (CAS CATO-C4X-222624)
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