N-(2,4-difluorophenyl)-6-(isopropylthio)nicotinamide CAS 339030-46-5

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2,4-difluorophenyl)-6-(isopropylthio)nicotinamide.

N-(2,4-difluorophenyl)-6-(isopropylthio)nicotinamide (CAS 339030-46-5), molecular formula C15H14F2N2OS and molecular weight 308.35 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of N-(2,4-difluorophenyl)-6-(isopropylthio)nicotinamide (C15H14F2N2OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), N-(2,4-difluorophenyl)-6-(isopropylthio)nicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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