(5-(Trifluoromethyl)pyridine-2,3-diyl)bis(phenylmethanone) CAS 339106-10-4
| CAS No. | 339106-10-4 |
| Molecular Formula | C20H12F3NO2 |
| Molecular Weight | 355.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (5-(Trifluoromethyl)pyridine-2,3-diyl)bis(phenylmethanone) (C20H12F3NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
(5-(Trifluoromethyl)pyridine-2,3-diyl)bis(phenylmethanone) (CAS 339106-10-4), molecular formula C20H12F3NO2 and molecular weight 355.31 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H12F3NO2 |
| Molecular Weight | 355.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- (2Z)-2-({[3-(trifluoromethyl)phenyl]amino}methylidene)-1H,2H-naphtho[2,1-b]furan-1-one (CAS 338415-27-3)
- 5-Phenyl-7-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ol (CAS 865546-64-1)
- N-(2-(4-(Trifluoromethyl)-5,6,7,8-tetrahydroquinazolin-2-yl)ethyl)thiophene-3-carboxamide (CAS 1396637-17-4)
- 2,2'-Bis(trifluoromethyl)-5-(difluoromethoxy)biphenyl (CAS 1261605-65-5)
- 1-(5-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)thiophen-2-yl)ethan-1-one (CAS 692287-80-2)
- 2-((3,5-bis(Trifluoromethyl)phenyl)amino)-1,3-thiazole-4-carboxylic acid (CAS 1797385-91-1)
- 5-(trifluoromethyl)-2-pyridyl 3-methyl-5-(trifluoromethyl)isoxazole-4-carbothioate (CAS 256488-21-8)
- 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(1,3-dioxan-2-yl)propan-1-one (CAS 884504-38-5)
Recommended Standards
- (E)-3-phenyl-5-(2-((3-(trifluoromethyl)phenyl)amino)vinyl)isoxazole-4-carbonitrile (CAS 303995-73-5)
- 3,4,5-Trimethoxy-N-(3-(trifluoromethyl)phenyl)benzamide (CAS 1543-72-2)
- 3-(((6-(4-Bromophenyl)hexyl)oxy)methyl)-3-ethyloxetane (CAS 746633-97-6)
- Allyl 2-deoxy-4,6-O-isopropylidene-2-(trifluoroacetamido)-a-D-glucopyranoside (CAS 139629-59-7)
- 3-((Phenylthio)methyl)piperidine (CAS 101798-81-6)
- 3-Methyl-6,7-dihydroisoxazolo[4,5-c]pyridin-4(5H)-one (CAS 164223-42-1)
- 5,7-Dihydrofuro[3,4-d]pyrimidine-2,4-diol (CAS 848398-40-3)
- 1-azaspiro[5.5]undec-7-en-2-one (CAS 56139-89-0)
- N-(2-Styryloxazol-5-yl)acetamide (CAS 87783-77-5)
- (4,6-Dihydroxy-1,3-phenylene)bis(phenylmethanone) (CAS 3088-15-1)
- 1-(2-Chlorobenzo[d]oxazol-4-yl)ethanone (CAS 1804105-83-6)
- Decanoyl-Arg-Arg-Leu-Leu-chloromethylketone (CAS 911379-57-2)
- 3-(5-Chloro-2-hydroxyphenyl)-2-methylacrylaldehyde (CAS 443872-86-4)
- Semaglutide impurity 40 (CAS CATO-C4X-222640)
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