(E)-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}({1-[2-(4-methoxyphenyl)cyclopropyl]ethylidene})amine CAS 341966-79-8
| CAS No. | 341966-79-8 |
| Molecular Formula | C18H16ClF3N2O2 |
| Molecular Weight | 384.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (E)-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}({1-[2-(4-methoxyphenyl)cyclopropyl]ethylidene})amine is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(E)-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}({1-[2-(4-methoxyphenyl)cyclopropyl]ethylidene})amine (CAS 341966-79-8) is a high-purity analytical reference standard with the molecular formula C18H16ClF3N2O2 and a molecular weight of 384.78 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, (E)-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}({1-[2-(4-methoxyphenyl)cyclopropyl]ethylidene})amine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 384.78 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H16ClF3N2O2 |
| Molecular Weight | 384.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related E Standards
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl benzoate (CAS 321430-22-2)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-(4-(pyridin-2-yl)piperazin-1-yl)ethan-1-one (CAS 477858-95-0)
- 4-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)benzamide (CAS 338979-27-4)
- 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-phenylpiperazine-1-carboxamide (CAS 856181-88-9)
- 2-(2-Chloro-4-nitrobenzenesulfonamido)-3-phenylpropanoic acid (CAS 1009582-33-5)
- Ethyl 4-(4-chloro-3-nitrobenzenesulfonamido)benzoate (CAS 16362-53-1)
- (E)-2-(2-((((2-chloro-6-fluorobenzyl)oxy)imino)methyl)-1H-pyrrol-1-yl)-4-methoxynicotinonitrile (CAS 339103-13-8)
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Recommended Standards
- 2-(2-Chlorophenyl)-1-{4-[6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl}ethan-1-one (CAS 1775313-01-3)
- 3,3,4-Tribromo-1,1,1,2,2-pentafluorobutane (CAS 1379361-16-6)
- 1-[(4-Chlorophenyl)methyl]-3-(pyrrolidine-1-carbonyl)-6-(trifluoromethyl)-1,2-dihydropyridin-2-one (CAS 551921-72-3)
- 1,2,2-TRibromo-1,1,4,4,4-pentafluorobutane (CAS 1309602-10-5)
- 3-(1H-Pyrazol-1-yl)butan-2-amine (CAS 956805-00-8)
- 5-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (CAS 1072009-08-5)
- N-(2,3-dimethylphenyl)-2-(4-formyl-2-methoxyphenoxy)acetamide (CAS 574711-16-3)
- 1-(Morpholin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (CAS 338396-51-3)
- Methyl 5-(p-tolyl)-1H-pyrazole-4-carboxylate (CAS 1150164-02-5)
- 3-tert-butyl-5-Chloro-6-(hydroxymethyl)-1H-pyrimidine-2,4-dione (CAS 25546-02-5)
- 4-(N-Acetyl)piperidinyl 2-(5-Methoxy)phenol Ketone (CAS 64671-18-7)
- Methyl 3-tert-butyl-1H-pyrazole-5-carboxylate (CAS 152307-84-1)
- 6-bromonaphthalene-1,2-diamine dihydrochloride (CAS 1909313-08-1)
- (Asp28)-Exenatide trifluoroacetate salt (CAS 1678417-24-7)
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