1-[2-Amino-5-chloro-4-(triisopropylsilyloxy)phenyl]-2,2,2-trifluoroethanone 1-[2-Amino-5-chloro-4-[[tris(1-methylethyl)silyl]oxy]phenyl]-2,2,2-trifluoroethanone 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline 342621-21-0 CAS 342621-21-0

Purity 97%+In StockPharmaceutical Standards
CAS No.342621-21-0
Molecular FormulaC17H25ClF3NO2Si
Molecular Weight395.92 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

1-[2-Amino-5-chloro-4-(triisopropylsilyloxy)phenyl]-2,2,2-trifluoroethanone 1-[2-Amino-5-chloro-4-[[tris(1-methylethyl)silyl]oxy]phenyl]-2,2,2-trifluoroethanone 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline 342621-21-0 CAS 342621-21-0 chemical structure

Description

1-[2-Amino-5-chloro-4-(triisopropylsilyloxy)phenyl]-2,2,2-trifluoroethanone 1-[2-Amino-5-chloro-4-[[tris(1-methylethyl)silyl]oxy]phenyl]-2,2,2-trifluoroethanone 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline 342621-21-0 (CAS 342621-21-0), molecular formula C17H25ClF3NO2Si and molecular weight 395.92 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 1-[2-Amino-5-chloro-4-(triisopropylsilyloxy)phenyl]-2,2,2-trifluoroethanone 1-[2-Amino-5-chloro-4-[[tris(1-methylethyl)silyl]oxy]phenyl]-2,2,2-trifluoroethanone 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline 342621-21-0 (C17H25ClF3NO2Si) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 1-[2-Amino-5-chloro-4-(triisopropylsilyloxy)phenyl]-2,2,2-trifluoroethanone 1-[2-Amino-5-chloro-4-[[tris(1-methylethyl)silyl]oxy]phenyl]-2,2,2-trifluoroethanone 2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyaniline 342621-21-0 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC17H25ClF3NO2Si
Molecular Weight395.92 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2025
Halogen ContentF/Cl-containing
Nitrogen Atoms1

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