(3-Chloropyridin-2-yl)methanamine dihydrochloride CAS 342816-31-3
| CAS No. | 342816-31-3 |
| Molecular Formula | C6H7ClN2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(3-Chloropyridin-2-yl)methanamine dihydrochloride (CAS 342816-31-3) is a high-purity analytical reference standard with the molecular formula C6H7ClN2HCl and a molecular weight of 179.04 g/mol.
The molecular framework of (3-Chloropyridin-2-yl)methanamine dihydrochloride (C6H7ClN2HCl) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN2 2*HCl |
| Molecular Weight | 179.04 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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- 2-(4-chloropyridin-2-yl)acetonitrile (CAS 1000515-40-1)
- 2-(5-Chloropyridin-2-yl)acetic acid (CAS 1000522-43-9)
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Recommended Standards
- 2-(5-methyl-1,3-thiazol-2-yl)ethan-1-amine dihydrochloride (CAS 1311317-94-8)
- Ethyl 5-methyl-2-oxopiperidine-3-carboxylate (CAS 102943-16-8)
- 2-Cyclohexyl-1-phenyl Ethylamine hydrochloride (CAS 82867-36-5)
- (S)-1-(Tetrahydro-2H-pyran-4-yl)ethan-1-ol (CAS 1567985-37-8)
- (R)-2-Amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid (CAS 108391-82-8)
- 5-Amino-7-benzyl-2-chloro-6,7,8,9-tetrahydropyrido[2,3-b][1,6]naphthyridine-3-carbonitrile (CAS 1263199-65-0)
- Ethyl 3-hydroxy-2-methylbenzoate (CAS 141607-09-2)
- 1-(6-Methyl-5,6,7,8-tetrahydrocinnolin-3-yl)pyrrolidin-3-amine (CAS 1707393-87-0)
- Z-N-Me-Ser(tBu)-OH . DCHA (C-4100.0001) (CAS 117106-19-1)
- FMRF Amide Related Peptide. (CAS 149471-12-5)
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