(3-Chloro-4-fluorophenyl)urea CAS 343247-57-4
| CAS No. | 343247-57-4 |
| Molecular Formula | C7H6ClFN2O |
| Molecular Weight | 188.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (3-Chloro-4-fluorophenyl)urea.
CATO supplies (3-Chloro-4-fluorophenyl)urea (CAS 343247-57-4), a certified reference material (molecular formula C7H6ClFN2O, MW 188.59 g/mol) for analytical method development and quality control.
The molecular framework of (3-Chloro-4-fluorophenyl)urea (C7H6ClFN2O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6ClFN2O |
| Molecular Weight | 188.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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- methyl (2S,6S)-6-methylmorpholine-2-carboxylate;hydrochloride (CAS 1969287-69-1)
- (R)-4-((R)-1-Hydroxyethyl)-3-(4-methoxybenzyl)oxazolidin-2-one (CAS 1628810-05-8)
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- Des-Ser39-Tirzepatide (CAS CATO-CPTD788936)
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