2-((6-Acetamidopyridin-3-yl)thio)-N-(4-(trifluoromethoxy)phenyl)nicotinamide CAS 343373-14-8
| CAS No. | 343373-14-8 |
| Molecular Formula | C20H15F3N4O3S |
| Molecular Weight | 448.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 448.42 g/mol gives 2-((6-Acetamidopyridin-3-yl)thio)-N-(4-(trifluoromethoxy)phenyl)nicotinamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-((6-Acetamidopyridin-3-yl)thio)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (CAS 343373-14-8), molecular formula C20H15F3N4O3S and molecular weight 448.42 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-((6-Acetamidopyridin-3-yl)thio)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (C20H15F3N4O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 448.42 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-((6-Acetamidopyridin-3-yl)thio)-N-(4-(trifluoromethoxy)phenyl)nicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H15F3N4O3S |
| Molecular Weight | 448.42 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Acetamidopyridin Standards
- N-(3-((6-Acetamidopyridin-3-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (CAS 1020536-13-3)
- 2-((6-Acetamidopyridin-3-yl)thio)-N-(4-(trifluoromethoxy)phenyl)benzamide (CAS 338962-78-0)
- 2-[(6-Acetamidopyridin-3-yl)sulfanyl]-N-{[3-(trifluoromethyl)phenyl]methyl}benzamide (CAS 343373-09-1)
- N-(3-((6-Acetamidopyridin-3-yl)oxy)-4-methylphenyl)-3-(4-fluorophenyl)-2-oxoimidazolidine-1-carboxamide (CAS 1020536-01-9)
- N-(3-((6-Acetamidopyridin-3-yl)oxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide (CAS 1020536-03-1)
- N-(5-((6-Acetamidopyridin-3-yl)oxy)-2-chlorophenyl)-3-(4-fluorophenyl)-2-oxoimidazolidine-1-carboxamide (CAS 1020536-04-2)
- 2-[(6-Acetamidopyridin-3-yl)sulfanyl]-N-(4-methoxyphenyl)pyridine-3-carboxamide (CAS 343373-15-9)
- 2-((6-Acetamidopyridin-3-yl)thio)-N-(4-methoxyphenyl)benzamide (CAS 338392-21-5)
Recommended Standards
- (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-hydroxy-3-nitrophenyl)propanoic acid (CAS 181952-16-9)
- 2-(3,4-Dimethoxybenzoyl)-6-(furan-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-3-amine (CAS 625377-62-0)
- 4-Methoxyphenyl 4-O-(b-D-galactopyranosyl)-β-D-glucopyranoside (CAS 150412-80-9)
- 2',4',6'-Trimethyl-[1,1':3',1''-terphenyl]-3,3'',5,5''-tetracarboxylicacid (CAS 2183479-06-1)
- Ethyl cyanide-<SUP>13</SUP>C,<SUP>15</SUP>N-acetate-1,2-<SUP>13</SUP>C<SUB>2</SUB> (CAS 1196157-67-1)
- 4-(4-Chlorobenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-5-(3-hydroxyphenyl)-1H-pyrrol-2(5H)-one (CAS 618074-52-5)
- trans-Decahydroquinoline (CAS 767-92-0)
- 3-(2,4-Dimethylphenyl)-1-methyl-1h-pyrazole-5-carboxylic acid (CAS 1015868-58-2)
- 5-Bromo-1-(2,2,2-trifluoroethyl)-1H-1,2,3-triazole (CAS 1393567-16-2)
- 2-(5-Nitroquinolin-8-yl)ethan-1-amine (CAS 1306605-86-6)
- 3-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidin-3-ol hydrochloride (CAS 1803606-38-3)
- 8-Methyl-5-nitroisoquinoline (CAS 1050267-63-4)
- 3-Cyanopicolinoyl chloride (CAS 856837-02-0)
- Insulin Degludec Impurity 6 (CAS CATO-C4X-21576)
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