3-[(2-Chloro-6-fluorophenyl)methanesulfonyl]-5-methyl-1,2-thiazole-4-carbonitrile CAS 343375-68-8
| CAS No. | 343375-68-8 |
| Molecular Formula | C12H8ClFN2O2S2 |
| Molecular Weight | 330.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 330.79 g/mol gives 3-[(2-Chloro-6-fluorophenyl)methanesulfonyl]-5-methyl-1,2-thiazole-4-carbonitrile distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 3-[(2-Chloro-6-fluorophenyl)methanesulfonyl]-5-methyl-1,2-thiazole-4-carbonitrile (CAS 343375-68-8), a certified reference material (molecular formula C12H8ClFN2O2S2, MW 330.79 g/mol) for analytical method development and quality control.
Based on its molecular formula C12H8ClFN2O2S2, 3-[(2-Chloro-6-fluorophenyl)methanesulfonyl]-5-methyl-1,2-thiazole-4-carbonitrile contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 330.79 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-[(2-Chloro-6-fluorophenyl)methanesulfonyl]-5-methyl-1,2-thiazole-4-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClFN2O2S2 |
| Molecular Weight | 330.79 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Chloro Standards
- 3-{[(3Z)-5-chloro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino}-1-phenylthiourea (CAS 1370320-21-0)
- 2-Chloro-N-[(5E)-5-[(3-fluorophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetamide (CAS 866154-63-4)
- 4-((2-Chloro-3-phenylallylidene)amino)-3-(furan-2-yl)-1H-1,2,4-triazole-5(4H)-thione (CAS 478253-73-5)
- 4-(4-Chloro-3-ethyl-3-methyl-2,5-dioxopyrrolidin-1-yl)benzenesulfonamide (CAS 65116-25-8)
- 6-Chloro-N-cyclopropyl-4-methanesulfonyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide (CAS 866142-51-0)
- (5E)-5-(3-Chloro-4-hydroxybenzylidene)-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one 497835-71-9 (CAS 497835-71-9)
- N-(3-Chloro-4-methoxyphenyl)-2-(2-mercapto-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetamide (CAS 1142206-98-1)
- N-(5-Chloro-2-methoxyphenyl)-2-(2-mercapto-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetamide (CAS 1142207-00-8)
Recommended Standards
- 3'-(4-Chlorophenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione (CAS 79962-57-5)
- 3-(3-Chlorophenyl)-4-((3-(furan-2-yl)allylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478255-25-3)
- 3-(2-Chlorophenyl)-4-((3-(furan-2-yl)allylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-35-2)
- 5-Methyl-2-(pyridin-2-yl)thiazol-4-yl 4-chlorobenzoate (CAS 338399-13-6)
- N-Butylcycloheptanamine hydrochloride (CAS 1609407-31-9)
- 4-Fluoroisoquinoline Sulfate (CAS 906820-09-5)
- 3-Amino-6-methyl-1-(2-(2-methylpiperidin-1-yl)-2-oxoethyl)pyridin-2(1H)-one (CAS 1443290-00-3)
- N-((3-Nitrophenyl)sulfonyl)benzamide (CAS 3409-79-8)
- Tert-butyl 3-isopropoxyazetidine-1-carboxylate (CAS 871657-51-1)
- Irinotecan Impurity 23 (CAS 946821-59-6)
- 2-((4-Phenylphthalazin-1-yl)amino)butan-1-ol (CAS 140214-77-3)
- Ethyl 2-amino-2-phenylacetate (CAS 6097-58-1)
- 3-[2-(2-Chloro-4,6-dimethylphenoxy)ethyl]-piperidine hydrochloride (CAS 1220030-08-9)
- C-Peptide (human) (CAS 33017-11-7)
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