4-Fluoro-2-nitro-6-(trifluoromethyl)aniline CAS 344-29-6
| CAS No. | 344-29-6 |
| Molecular Formula | C7H4F4N2O2 |
| Molecular Weight | 224.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4-Fluoro-2-nitro-6-(trifluoromethyl)aniline (CAS 344-29-6), a certified reference material (molecular formula C7H4F4N2O2, MW 224.11 g/mol) for analytical method development and quality control.
The molecular framework of 4-Fluoro-2-nitro-6-(trifluoromethyl)aniline (C7H4F4N2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Fluoro-2-nitro-6-(trifluoromethyl)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4F4N2O2 |
| Molecular Weight | 224.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
- 2-Fluoro-4-(trifluoromethoxy)benzoic acid (CAS 1073477-22-1)
- 5-Fluoro-2-(trifluoromethoxy)benzoic acid (CAS 1092460-83-7)
- 2-Fluoro-3-(trifluoromethoxy)benzoic acid (CAS 1159512-62-5)
- 2-Fluoro-6-(trifluoromethoxy)benzoic acid (CAS 1211530-22-1)
- 2-Fluoro-6-nitro-4-(trifluoromethyl)aniline (CAS 1217304-18-1)
- 4-Fluoro-2-(trifluoromethoxy)benzoic acid (CAS 1242250-37-8)
- 3-Fluoro-2-(trifluoromethoxy)benzoic acid (CAS 1242252-50-1)
- 3-Fluoro-5-(trifluoromethoxy)benzoic Acid (CAS 1242258-49-6)
Recommended Standards
- 4,6-Dichloro-N-methyl-5-(methylthio)pyrimidin-2-amine (CAS 40765-72-8)
- 4-Fluoro-3-(trifluoromethoxy)benzoic acid (CAS 886496-49-7)
- 3-Fluoro-4-(trifluoromethoxy)benzoic Acid (CAS 886498-89-1)
- 5-Fluoro-2-nitro-4-(trifluoromethyl)aniline (CAS 428871-73-2)
- 2-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic Acid (CAS 913689-08-4)
- Methyl 19-methyleicosanoate (CAS 95799-86-3)
- (R)-2-Amino-3-(thiazol-4-yl)propanoic acid (CAS 131896-42-9)
- Actarit-d4 (CAS 1189999-98-1)
- Acetyl Isoniazid-d4 (CAS 1330169-81-7)
- methyl[3-(propan-2-yloxy)propyl]amine hydrochloride (CAS 1864061-53-9)
- 2-Benzyl-4-oxocyclohexane-1-carboxylic acid (CAS 418797-33-8)
- 3-Bromo-5,5-dimethyl-4,5-dihydroisoxazole (CAS 882697-80-5)
- Ethylenecyclohexane (CAS 1003-64-1)
- Rac1 Inhibitor F56, control peptide (CAS 1315378-77-8)
Why CATO?
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