4-(4-Chlorophenyl)-2-(3-fluorophenyl)-4-oxobutanoic acid CAS 344280-97-3
| CAS No. | 344280-97-3 |
| Molecular Formula | C16H12ClFO3 |
| Molecular Weight | 306.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-(4-Chlorophenyl)-2-(3-fluorophenyl)-4-oxobutanoic acid (CAS 344280-97-3), molecular formula C16H12ClFO3 and molecular weight 306.72 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(4-Chlorophenyl)-2-(3-fluorophenyl)-4-oxobutanoic acid (C16H12ClFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 4-(4-Chlorophenyl)-2-(3-fluorophenyl)-4-oxobutanoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12ClFO3 |
| Molecular Weight | 306.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chlorophenyl Standards
- 4-(4-Chlorophenyl)-2-(4-fluorophenyl)-4-oxobutanoic acid (CAS 344280-79-1)
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- N-(4-chlorophenyl)-4-(trifluoromethyl)piperidine-1-carboxamide (CAS 264924-43-8)
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