3-(4-Fluorophenyl)-4,5-dihydro-1H-pyrazole CAS 344752-82-5
| CAS No. | 344752-82-5 |
| Molecular Formula | C9H9FN2 |
| Molecular Weight | 164.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(4-Fluorophenyl)-4,5-dihydro-1H-pyrazole (CAS 344752-82-5), molecular formula C9H9FN2 and molecular weight 164.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(4-Fluorophenyl)-4,5-dihydro-1H-pyrazole (C9H9FN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9FN2 |
| Molecular Weight | 164.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluorophenyl Standards
- 2-(2-Fluorophenyl)but-3-yn-2-ol (CAS 104684-14-2)
- 3-(2-Fluorophenyl)cyclobutanone (CAS 1080636-31-2)
- 3-(3-Fluorophenyl)cyclobutanone (CAS 1080636-45-8)
- 2-(4-fluorophenyl)cyclopropane-1-carbaldehyde (CAS 1233026-05-5)
- 1-(2-Fluorophenyl)cyclopropane-1-carbaldehyde (CAS 1267971-50-5)
- 5-(4-Fluorophenyl)-4,5-dihydro-1H-pyrazole (CAS 1337564-73-4)
- (E)-1-(2-Fluorophenyl)but-2-en-1-one (CAS 1360924-06-6)
- (E)-3-(2-fluorophenyl)-2-methylacrylaldehyde (CAS 1375800-37-5)
Recommended Standards
- 3-(2-Fluorophenyl)-4,5-dihydro-1H-pyrazole (CAS 361442-71-9)
- 3-(difluoromethyl)-1-methyl-pyrazole-4-thiol (CAS 2055255-83-7)
- 2-Fluoro-2-methyl-2,3-dihydro-1H-inden-1-one (CAS 242793-47-1)
- 3,4-Dimethoxy-1,2,5-thiadiazole 1-oxide (CAS 78441-23-3)
- N-(4-(2-Oxo-2-(pyrrolidin-1-yl)ethyl)phenyl)acetamide (CAS 1009905-97-8)
- Bromobenzene-d5 (CAS 4165-57-5)
- tert-Butyl 5-bromo-4-nitrothiophene-2-carboxylate (CAS 62224-29-7)
- (E)-1-(1H-Imidazol-1-yl)-3-phenylprop-2-en-1-one (CAS 1138-15-4)
- (S,S,S)-(-)-Tol-SKP (CAS 1548897-80-8)
- 5-Chloro-4-(((4-fluorophenyl)thio)methyl)-1,2,3-thiadiazole (CAS 338761-78-7)
- (2R)-2-amino-2-(4-chlorophenyl)ethanol (CAS 1067658-27-8)
- (S)-5-Bromo-2,3-dihydro-1H-inden-2-amine hydrochloride (CAS 370861-68-0)
- 1,2-Dimethyl-9H-carbazole (CAS 18992-67-1)
- Liraglutide Sodium Salt (CAS 204656-20-2（free base）)
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